ID   UTS2_PIG                Reviewed;         121 AA.
AC   Q95J46; Q95K72;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Urotensin-2;
DE   AltName: Full=Urotensin II;
DE            Short=U-II;
DE            Short=UII;
DE   Flags: Precursor;
GN   Name=UTS2;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Spinal cord;
RX   PubMed=10548501; DOI=10.1006/bbrc.1999.1640;
RA   Mori M., Sugo T., Abe M., Shimomura Y., Kurihara M., Kitada C., Kikuchi K.,
RA   Shintani Y., Kurokawa T., Onda H., Nishimura O., Fujino M.;
RT   "Urotensin II is the endogenous ligand of a G-protein-coupled orphan
RT   receptor, SENR (GPR14).";
RL   Biochem. Biophys. Res. Commun. 265:123-129(1999).
CC   -!- FUNCTION: Highly potent vasoconstrictor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q95J46-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q95J46-2; Sequence=VSP_012041;
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   EMBL; AB063244; BAB60887.1; -; mRNA.
DR   EMBL; AB063245; BAB60888.1; -; mRNA.
DR   EMBL; AB063246; BAB60889.1; -; mRNA.
DR   RefSeq; NP_999308.1; NM_214143.1. [Q95J46-1]
DR   AlphaFoldDB; Q95J46; -.
DR   STRING; 9823.ENSSSCP00000019973; -.
DR   PaxDb; Q95J46; -.
DR   Ensembl; ENSSSCT00035050006; ENSSSCP00035020015; ENSSSCG00035037730. [Q95J46-2]
DR   Ensembl; ENSSSCT00035050014; ENSSSCP00035020020; ENSSSCG00035037730. [Q95J46-1]
DR   GeneID; 397268; -.
DR   KEGG; ssc:397268; -.
DR   CTD; 10911; -.
DR   eggNOG; ENOG502SCRX; Eukaryota.
DR   InParanoid; Q95J46; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cleavage on pair of basic residues; Disulfide bond;
KW   Hormone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   PROPEP          20..106
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036353"
FT   PEPTIDE         110..121
FT                   /note="Urotensin-2"
FT                   /id="PRO_0000036354"
FT   DISULFID        115..120
FT                   /evidence="ECO:0000250"
FT   VAR_SEQ         34..69
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:10548501"
FT                   /id="VSP_012041"
SQ   SEQUENCE   121 AA;  13580 MW;  656E4B01AF69101B CRC64;
     MSKLVPCLLL LGCLGLLFAL PVPDSRKEPL PFSAPEDVRS AWDELERASL LQMLPETPGA
     EAGEDLREAD AGMDIFYPRG EMRKAFSGQD PNIFLSHLLA RIKKPYKKRG PPSECFWKYC
     V