ID   UTS2_PLAFE              Reviewed;          83 AA.
AC   P21857;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1991, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Urotensin-2;
DE   AltName: Full=Urotensin II;
DE            Short=U-II;
DE            Short=UII;
DE   Contains:
DE     RecName: Full=Urotensin-2 beta;
DE   Flags: Precursor; Fragments;
OS   Platichthys flesus (European flounder) (Pleuronectes flesus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Carangaria; Pleuronectiformes; Pleuronectoidei; Pleuronectidae;
OC   Platichthys.
OX   NCBI_TaxID=8260;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Urophysis;
RX   PubMed=2365069; DOI=10.1016/0014-5793(90)81500-n;
RA   Conlon J.M., Arnold-Reed D.E., Balment R.J.;
RT   "Post-translational processing of prepro-urotensin II.";
RL   FEBS Lett. 266:37-40(1990).
CC   -!- FUNCTION: Urotensin is found in the teleost caudal neurosecretory
CC       system. It has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor. The non-hormonal portion of this
CC       precursor may be a urotensin binding protein, urophysin.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   PIR; S10706; S10706.
DR   AlphaFoldDB; P21857; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Hormone; Secreted.
FT   CHAIN           1..>48
FT                   /note="Urotensin-2"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036341"
FT   PROPEP          <49..>71
FT                   /id="PRO_0000036342"
FT   PEPTIDE         72..83
FT                   /note="Urotensin-2 beta"
FT                   /id="PRO_0000036343"
FT   DISULFID        77..82
FT   NON_CONS        48..49
FT                   /evidence="ECO:0000305"
FT   NON_CONS        71..72
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   83 AA;  9293 MW;  6DD057577E6DF703 CRC64;
     HPITESAEMP YPGPASLEER GVGSLDDLSL SEQNYPPQRG AGLRYATLEV LLEKQSLLNP
     FSRVFGIRKQ FAGTTECFWK YCV