ID   UTS2_POLSP              Reviewed;          12 AA.
AC   P81022;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   07-APR-2021, entry version 46.
DE   RecName: Full=Urotensin-2;
DE   AltName: Full=Urotensin II;
DE            Short=U-II;
DE            Short=UII;
OS   Polyodon spathula (North American paddlefish) (Squalus spathula).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Chondrostei; Acipenseriformes; Polyodontidae; Polyodon.
OX   NCBI_TaxID=7913;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Spinal cord;
RX   PubMed=8536944; DOI=10.1006/gcen.1995.1116;
RA   Waugh D., Youson J., Mims S.D., Sower S., Conlon J.M.;
RT   "Urotensin II from the river lamprey (Lampetra fluviatilis), the sea
RT   lamprey (Petromyzon marinus), and the paddlefish (Polyodon spathula).";
RL   Gen. Comp. Endocrinol. 99:323-332(1995).
CC   -!- FUNCTION: Has a suggested role in osmoregulation and as a
CC       corticotropin-releasing factor. Probably involved in smooth muscle
CC       stimulation.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IEA:InterPro.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:InterPro.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hormone; Secreted.
FT   PEPTIDE         1..12
FT                   /note="Urotensin-2"
FT                   /id="PRO_0000044569"
FT   DISULFID        6..11
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   12 AA;  1410 MW;  7551E9DBB879CEBB CRC64;
     GSTSECFWKY CV