ID   UTS2_RAT                Reviewed;         123 AA.
AC   Q9QZQ4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Urotensin-2;
DE   AltName: Full=Urotensin II;
DE            Short=U-II;
DE            Short=UII;
DE   Flags: Precursor;
GN   Name=Uts2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spinal cord;
RX   PubMed=10486557; DOI=10.1016/s0014-5793(99)01003-0;
RA   Coulouarn Y., Jegou S., Tostivint H., Vaudry H., Lihrmann I.;
RT   "Cloning, sequence analysis and tissue distribution of the mouse and rat
RT   urotensin II precursors.";
RL   FEBS Lett. 457:28-32(1999).
CC   -!- FUNCTION: Highly potent vasoconstrictor. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Brain specific.
CC   -!- SIMILARITY: Belongs to the urotensin-2 family. {ECO:0000305}.
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DR   EMBL; AF172174; AAD55766.1; -; mRNA.
DR   RefSeq; NP_062033.1; NM_019160.2.
DR   AlphaFoldDB; Q9QZQ4; -.
DR   STRING; 10116.ENSRNOP00000024798; -.
DR   BindingDB; Q9QZQ4; -.
DR   PaxDb; Q9QZQ4; -.
DR   Ensembl; ENSRNOT00000024798; ENSRNOP00000024798; ENSRNOG00000018393.
DR   GeneID; 29180; -.
DR   KEGG; rno:29180; -.
DR   UCSC; RGD:3930; rat.
DR   CTD; 10911; -.
DR   RGD; 3930; Uts2.
DR   eggNOG; ENOG502SCRX; Eukaryota.
DR   GeneTree; ENSGT00510000049583; -.
DR   HOGENOM; CLU_156959_0_0_1; -.
DR   InParanoid; Q9QZQ4; -.
DR   OMA; IISFSCP; -.
DR   OrthoDB; 1506988at2759; -.
DR   PhylomeDB; Q9QZQ4; -.
DR   TreeFam; TF330799; -.
DR   Reactome; R-RNO-375276; Peptide ligand-binding receptors.
DR   Reactome; R-RNO-416476; G alpha (q) signalling events.
DR   PRO; PR:Q9QZQ4; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000018393; Expressed in duodenum and 5 other tissues.
DR   Genevisible; Q9QZQ4; RN.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0097746; P:blood vessel diameter maintenance; IDA:RGD.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IDA:RGD.
DR   GO; GO:0003105; P:negative regulation of glomerular filtration; IDA:RGD.
DR   GO; GO:0010459; P:negative regulation of heart rate; IDA:RGD.
DR   GO; GO:0046676; P:negative regulation of insulin secretion; IMP:RGD.
DR   GO; GO:0035814; P:negative regulation of renal sodium excretion; IDA:RGD.
DR   GO; GO:0035811; P:negative regulation of urine volume; IDA:RGD.
DR   GO; GO:0045766; P:positive regulation of angiogenesis; IDA:RGD.
DR   GO; GO:0045777; P:positive regulation of blood pressure; IDA:RGD.
DR   GO; GO:0045597; P:positive regulation of cell differentiation; IDA:RGD.
DR   GO; GO:0046005; P:positive regulation of circadian sleep/wake cycle, REM sleep; IDA:RGD.
DR   GO; GO:0010841; P:positive regulation of circadian sleep/wake cycle, wakefulness; IDA:RGD.
DR   GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IDA:RGD.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IDA:RGD.
DR   GO; GO:0010763; P:positive regulation of fibroblast migration; IDA:RGD.
DR   GO; GO:0048146; P:positive regulation of fibroblast proliferation; IDA:RGD.
DR   GO; GO:0010460; P:positive regulation of heart rate; IDA:RGD.
DR   GO; GO:0032224; P:positive regulation of synaptic transmission, cholinergic; IDA:RGD.
DR   GO; GO:0008217; P:regulation of blood pressure; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:0033574; P:response to testosterone; IEP:RGD.
DR   GO; GO:0009410; P:response to xenobiotic stimulus; IEP:RGD.
DR   InterPro; IPR001483; Urotensin_II.
DR   Pfam; PF02083; Urotensin_II; 1.
DR   PROSITE; PS00984; UROTENSIN_II; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Hormone;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..104
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000036355"
FT   PEPTIDE         110..123
FT                   /note="Urotensin-2"
FT                   /id="PRO_0000036356"
FT   REGION          63..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        117..122
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   123 AA;  13614 MW;  E4F1A8EE124AF1EA CRC64;
     MDRVPFCCLL FVGLLNPLLS FPVTDTGEMS LQLPVLEENA LRALEELERT ALLQTLRQTV
     GTEAEGSLGQ ADPSAETPTP RGSLRKALTG QDSNTVLSRL LARTRKQRKQ HGTAPECFWK
     YCI