ID   UUPL_HAEIN              Reviewed;         459 AA.
AC   P45167;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=ATP-binding protein Uup-like;
DE            EC=3.6.1.- {ECO:0000250|UniProtKB:P43672};
GN   Name=uup-B; OrderedLocusNames=HI_1342;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Might play a role in ribosome assembly or function; this is
CC       missing the first ABC transporter domain compared to paralogs.
CC       {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC         Evidence={ECO:0000250|UniProtKB:P43672};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P43672}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCF family.
CC       Uup subfamily. {ECO:0000305}.
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DR   EMBL; L42023; AAC22987.1; -; Genomic_DNA.
DR   PIR; B64171; B64171.
DR   RefSeq; NP_439494.1; NC_000907.1.
DR   AlphaFoldDB; P45167; -.
DR   SMR; P45167; -.
DR   STRING; 71421.HI_1342; -.
DR   EnsemblBacteria; AAC22987; AAC22987; HI_1342.
DR   KEGG; hin:HI_1342; -.
DR   PATRIC; fig|71421.8.peg.1395; -.
DR   eggNOG; COG0488; Bacteria.
DR   HOGENOM; CLU_000604_36_2_6; -.
DR   OMA; GKISANI; -.
DR   PhylomeDB; P45167; -.
DR   BioCyc; HINF71421:G1GJ1-1368-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   Gene3D; 1.10.287.380; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR032524; ABC_tran_C.
DR   InterPro; IPR032781; ABC_tran_Xtn.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR037118; Val-tRNA_synth_C_sf.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF16326; ABC_tran_CTD; 1.
DR   Pfam; PF12848; ABC_tran_Xtn; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Hydrolase; Nucleotide-binding; Reference proteome.
FT   CHAIN           1..459
FT                   /note="ATP-binding protein Uup-like"
FT                   /id="PRO_0000093031"
FT   DOMAIN          132..350
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          357..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         164..171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   459 AA;  52467 MW;  B4C1532C4EBCAA8E CRC64;
     MEAIEWLENF LLDFQGSIVF ISHDRSVIRK MATRIVDLDR GQLQSYLGNY DLYLTTKEEN
     LRVEALQNEL FDKRLAQEDV WIRQGIKARR TRNEGRVRAL KAMREERRQR REVMGTAKLQ
     LDTSSRSGKI VFEMEDVSYE IAGKTLLKDF STTILRGDKI ALVGPNGCGK TTFIKLLLGE
     IQPTSGKIRC GTKLEIAYFD QYRADLDPEK IVMDNVADGK QDIEINGVKR HVLGYLQEFL
     FPPKRAMTPV KALSGGERNR LLLAKLLLKP NNLLILDEPT NDLDVETLEL LEEILTDYQG
     TLLIVSHDRQ FIDNTATECY LFEGEGRLNK YVGGFFDAKQ QQANFWASKA VEEQAKAKKS
     EPLKEESAVK NDRTSKPKSV KLSYKEQREL EQLPQLLEEL ETKITTLQAE IADPAFFQQA
     HDITDAKLKA LADTEAELET AFLRWEELEE KKNLADGKA