ID   UVE1_NEUCR              Reviewed;         656 AA.
AC   Q01408; Q7RVT6;
DT   06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 2.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=UV-damage endonuclease;
DE            Short=UV-endonuclease;
DE            EC=3.-.-.-;
DE   AltName: Full=Mutagen-sensitive protein 18;
GN   Name=mus-18; Synonyms=uve1; ORFNames=5E6.270, NCU08850;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=7774597; DOI=10.1002/j.1460-2075.1995.tb07234.x;
RA   Yajima H., Takao M., Yasuhira S., Zhao J.H., Ishii C., Inoue H., Yasui A.;
RT   "A eukaryotic gene encoding an endonuclease that specifically repairs DNA
RT   damaged by ultraviolet light.";
RL   EMBO J. 14:2393-2399(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Endonuclease for the repair of UV-irradiated DNA. Involved in
CC       the excision of cyclobutane pyrimidine dimers (CPD) and 6-4 pyrimidine
CC       pyrimidones (6-4PP) which forms the UV damage repair (UVDR) pathway.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC   -!- SIMILARITY: Belongs to the uve1/UvsE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA31744.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; D11392; BAA74539.1; -; mRNA.
DR   EMBL; AL670004; CAD21267.1; -; Genomic_DNA.
DR   EMBL; CM002240; EAA31744.2; ALT_INIT; Genomic_DNA.
DR   PIR; S55262; S55262.
DR   RefSeq; XP_960980.2; XM_955887.2.
DR   AlphaFoldDB; Q01408; -.
DR   SMR; Q01408; -.
DR   STRING; 5141.EFNCRP00000008795; -.
DR   PRIDE; Q01408; -.
DR   EnsemblFungi; EAA31744; EAA31744; NCU08850.
DR   GeneID; 3877135; -.
DR   KEGG; ncr:NCU08850; -.
DR   HOGENOM; CLU_017168_1_0_1; -.
DR   InParanoid; Q01408; -.
DR   OMA; ANPPVFC; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0043504; P:mitochondrial DNA repair; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR   GO; GO:0009411; P:response to UV; IEA:InterPro.
DR   InterPro; IPR004601; UvdE.
DR   InterPro; IPR036237; Xyl_isomerase-like_sf.
DR   PANTHER; PTHR31290; PTHR31290; 1.
DR   Pfam; PF03851; UvdE; 1.
DR   SUPFAM; SSF51658; SSF51658; 1.
DR   TIGRFAMs; TIGR00629; uvde; 1.
PE   2: Evidence at transcript level;
KW   DNA damage; DNA excision; DNA repair; Endonuclease; Hydrolase; Nuclease;
KW   Reference proteome.
FT   CHAIN           1..656
FT                   /note="UV-damage endonuclease"
FT                   /id="PRO_0000215028"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          119..146
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          175..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          241..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          492..515
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..620
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          636..656
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        550..566
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..614
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   656 AA;  74413 MW;  4B231E7A8735C86F CRC64;
     MPSRKSKAAA LDTPQSESST FSSTLDSSAP SPARNLRRSG RNILQPSSEK DRDHEKRSGE
     ELAGRMMGKD ANGHCLREGK EQEEGVKMAI EGLARMERRL QRATKRQKKQ LEEDGIPVPS
     VVSRFPTAPY HHKSTNAEER EAKEPVLKTH SKDVEREAEI GVDDVVKMEP AATNIIEPED
     AQDAAERGAA RPPAVNSSYL PLPWKGRLGY ACLNTYLRNA KPPIFSSRTC RMASIVDHRH
     PLQFEDEPEH HLKNKPDKSK EPQDELGHKF VQELGLANAR DIVKMLCWNE KYGIRFLRLS
     SEMFPFASHP VHGYKLAPFA SEVLAEAGRV AAELGHRLTT HPGQFTQLGS PRKEVVESAI
     RDLEYHDELL SLLKLPEQQN RDAVMIIHMG GQFGDKAATL ERFKRNYARL SQSCKNRLVL
     ENDDVGWTVH DLLPVCEELN IPMVLDYHHH NICFDPAHLR EGTLDISDPK LQERIANTWK
     RKGIKQKMHY SEPCDGAVTP RDRRKHRPRV MTLPPCPPDM DLMIEAKDKE QAVFELMRTF
     KLPGFEKIND MVPYDRDDEN RPAPPVKAPK KKKGGKRKRT TDEEAAEPEE VDTAADDVKD
     APEGPKEVPE EERAMGGPYN RVYWPLGCEE WLKPKKREVK KGKVPEEVED EGEFDG