CAE12_RANCI
ID CAE12_RANCI Reviewed; 10 AA.
AC P62540; P82086;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 10-FEB-2021, entry version 37.
DE RecName: Full=Caerulein-1.2/1.2Y4;
OS Ranoidea citropa (Australian Blue Mountains tree frog) (Litoria citropa).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX NCBI_TaxID=94770;
RN [1]
RP PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, SULFATION AT TYR-4,
RP AMIDATION AT PHE-10, AND MASS SPECTROMETRY.
RC TISSUE=Skin secretion;
RX PubMed=10589099;
RX DOI=10.1002/(sici)1097-0231(19991230)13:24<2498::aid-rcm817>3.0.co;2-e;
RA Wabnitz P.A., Bowie J.H., Tyler M.J.;
RT "Caerulein-like peptides from the skin glands of the Australian blue
RT mountains tree frog Litoria citropa. Part 1. Sequence determination using
RT electrospray mass spectrometry.";
RL Rapid Commun. Mass Spectrom. 13:2498-2502(1999).
CC -!- FUNCTION: Hypotensive neuropeptide. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC -!- PTM: Isoform 1.2Y4 differs from isoform 1.2 in not being sulfated.
CC {ECO:0000269|PubMed:10589099}.
CC -!- MASS SPECTROMETRY: Mass=1366; Method=Electrospray; Note=Isoform
CC caerulein-1.2.; Evidence={ECO:0000269|PubMed:10589099};
CC -!- MASS SPECTROMETRY: Mass=1286; Method=Electrospray; Note=Isoform
CC caerulein-1.2Y4.; Evidence={ECO:0000269|PubMed:10589099};
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Direct protein sequencing;
KW Hypotensive agent; Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT PEPTIDE 1..10
FT /note="Caerulein-1.2/1.2Y4"
FT /id="PRO_0000043878"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:10589099"
FT MOD_RES 4
FT /note="Sulfotyrosine; in form caerulein-1.2"
FT /evidence="ECO:0000269|PubMed:10589099"
FT MOD_RES 10
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:10589099"
SQ SEQUENCE 10 AA; 1306 MW; 99DBFCD37861BB5A CRC64;
QQDYTGWFDF