ID   CAE12_RANSP             Reviewed;          10 AA.
AC   P62541; P82086;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   10-FEB-2021, entry version 37.
DE   RecName: Full=Caerulein-1.2;
OS   Ranoidea splendida (Magnificent tree frog) (Litoria splendida).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX   NCBI_TaxID=30345;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, AMIDATION AT PHE-10,
RP   AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=10601876; DOI=10.1046/j.1432-1327.2000.01010.x;
RA   Wabnitz P.A., Bowie J.H., Tyler M.J., Wallace J.C., Smith B.P.;
RT   "Differences in the skin peptides of the male and female Australian tree
RT   frog Litoria splendida. The discovery of the aquatic male sex pheromone
RT   splendipherin, together with Phe8 caerulein and a new antibiotic peptide
RT   caerin 1.10.";
RL   Eur. J. Biochem. 267:269-275(2000).
CC   -!- FUNCTION: Hypotensive neuropeptide. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC   -!- MASS SPECTROMETRY: Mass=1366; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:10601876};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Hypotensive agent; Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT   PEPTIDE         1..10
FT                   /note="Caerulein-1.2"
FT                   /id="PRO_0000043879"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:10601876"
FT   MOD_RES         4
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         10
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:10601876"
SQ   SEQUENCE   10 AA;  1306 MW;  99DBFCD37861BB5A CRC64;
     QQDYTGWFDF