UVRA_ALKHC
ID UVRA_ALKHC Reviewed; 957 AA.
AC Q9K6Y0;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=BH3594;
OS Alkalihalobacillus halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344
OS / JCM 9153 / C-125) (Bacillus halodurans).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Alkalihalobacillus.
OX NCBI_TaxID=272558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125;
RX PubMed=11058132; DOI=10.1093/nar/28.21.4317;
RA Takami H., Nakasone K., Takaki Y., Maeno G., Sasaki R., Masui N., Fuji F.,
RA Hirama C., Nakamura Y., Ogasawara N., Kuhara S., Horikoshi K.;
RT "Complete genome sequence of the alkaliphilic bacterium Bacillus halodurans
RT and genomic sequence comparison with Bacillus subtilis.";
RL Nucleic Acids Res. 28:4317-4331(2000).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; BA000004; BAB07313.1; -; Genomic_DNA.
DR PIR; B84099; B84099.
DR RefSeq; WP_010899722.1; NC_002570.2.
DR AlphaFoldDB; Q9K6Y0; -.
DR SMR; Q9K6Y0; -.
DR STRING; 272558.10176218; -.
DR EnsemblBacteria; BAB07313; BAB07313; BAB07313.
DR KEGG; bha:BH3594; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_2_1_9; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000001258; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..957
FT /note="UvrABC system protein A"
FT /id="PRO_0000093034"
FT DOMAIN 309..587
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 607..935
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 252..279
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 738..764
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 639..646
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 957 AA; 106441 MW; F183A6C84C5CC9CB CRC64;
MGLDNIVVKG ARSHNLKNID VTIPRDKLVV LTGLSGSGKS SLAFDTIYAE GQRRYVESLS
AYARQFLGQM DKPDVDSIEG LSPAISIDQK TTSRNPRSTV GTVTEIFDYL RLLYARIGKP
VCPKHGIEIS SQTVQQMVDR ILSYEERTKL QILAPLVSGR KGTHVKVLED IKKQGFVRVR
IDGEMREVAE EIELDKNKKH TIEVVIDRIV VKEGIETRLA DSLETALQLA DGRVVVDIIG
KEELLFSQHH ACPQCGFSIP ELEPRMFSFN SPFGACPTCD GLGVKLEVDL ELVIPDRSRT
LSENAIAPWE PISSQYYPQM LEAVCNHYGI DMDTPVEQLP DHQLEKILYG SGHEKIFFRY
ENDLGQVREN EILFEGVIPN VKRRYHETSS DYIRDQLEAY MAQKACPTCK GHRLKKEALA
VLIGGKHLGE VTKLSIKEAK TFFESLELSK KDFSIARLIL KEINDRLGFL MNVGLDYLTL
SRSAGTLSGG EAQRIRLATQ IGSSLMGVLY ILDEPSIGLH QRDNDRLIST LAHMRDLGNT
LIVVEHDEDT MLAADYIIDI GPGAGVHGGQ VTAAGSPEEI MNDAKSLTGQ YLSGKKFIPI
PSERRQPNGR SFTVKGASEN NLKQVNVEFP LGVFIAVTGV SGSGKSTLIN EIVHKALAQK
LHRAKDKPGK HKEIVGIEHV DKVIDIDQSP IGRTPRSNPA TYTGVFDDIR DVFAMTNEAK
VRGYKKGRFS FNVKGGRCEA CRGDGIIKIE MHFLPDVYVP CEVCHGKRYN RETLDITYKG
KTIADVLDMT VEEALEFFTN IPRIKRKIQT LVDVGLGYIK LGQPATTLSG GEAQRVKLAS
QLHKRATGKT LYILDEPTTG LHVDDIDRLL KVLQRIVDNG DTVLVIEHNL DVIKTVDHII
DLGPEGGDKG GTIVAQGTPE EVVEVEGSYT GKYLRPILER DRKRMDSRIR EHELQRS
