UVRA_BRUAB
ID UVRA_BRUAB Reviewed; 974 AA.
AC P0C0Z2; Q07433; Q57D33;
DT 07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-FEB-2006, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=BruAb1_1110;
OS Brucella abortus biovar 1 (strain 9-941).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX NCBI_TaxID=262698;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=9-941;
RX PubMed=15805518; DOI=10.1128/jb.187.8.2715-2726.2005;
RA Halling S.M., Peterson-Burch B.D., Bricker B.J., Zuerner R.L., Qing Z.,
RA Li L.-L., Kapur V., Alt D.P., Olsen S.C.;
RT "Completion of the genome sequence of Brucella abortus and comparison to
RT the highly similar genomes of Brucella melitensis and Brucella suis.";
RL J. Bacteriol. 187:2715-2726(2005).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE017223; AAX74451.1; -; Genomic_DNA.
DR RefSeq; WP_002964233.1; NC_006932.1.
DR AlphaFoldDB; P0C0Z2; -.
DR SMR; P0C0Z2; -.
DR EnsemblBacteria; AAX74451; AAX74451; BruAb1_1110.
DR GeneID; 3787776; -.
DR KEGG; bmb:BruAb1_1110; -.
DR HOGENOM; CLU_001370_0_1_5; -.
DR OMA; PFEGIIP; -.
DR PRO; PR:P0C0Z2; -.
DR Proteomes; UP000000540; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..974
FT /note="UvrABC system protein A"
FT /id="PRO_0000093038"
FT DOMAIN 331..610
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 630..959
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 762..788
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 663..670
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 974 AA; 107423 MW; 15F7C2BADB7B3127 CRC64;
MSDQKFISIR GAREHNLKNV DLDLPRDKLI VMTGLSGSGK SSLAFDTIYA EGQRRYVESL
SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSRNPRST VGTVTEIYDY MRLLFARVGI
PYSPATGLPI ESQTVSQMVD RVIALEEGTR LYILAPIVRG RKGEYRKELA ELQKKGFQRV
KVDGTFYEIA DVPPLDKKYK HDIDVVVDRV VVRPDLSTRL ADSLETCLKL ADGLAIAEFA
DKPLPVGETA EGGSANKSAN ETHERILFSE KFACPVSGFT IPEIEPRLFS FNNPFGACPT
CDGLGTQQAI DPNLIIPDES AALKDGAVAP WARSSSPYYN QTLEALGKAY GFKVSARWSE
LSEEARQAIL YGTKGREITF HYDDGLRSYQ TTKPFEGVIP NLERRWKETD SAWSREEIER
FMASTPCPAC NGYRLKPEAL SVKIGKKHIG EITEMSIRKA DAWFRDIDGS FNEKQREIAA
RILKAIRERL QFLNNVGLDY LTLARNSGTL SGGESQRIRL ASQIGSGLTG VLYVLDEPSI
GLHQRDNARL LDTLRHLRDL GNTVIVVEHD EDAILTADYV VDIGPAAGVH GGKVIAQGSP
QDIMANTNSL TGKYLSGAME VAVPAERRKI SKTKRLRVVG ARGNNLKNVS ADIPLGTFTA
VTGVSGGGKS TFLIETLFKA ASRRIMGSRE HPAEHDRIEG LEFLDKVIDI DQSPIGRTPR
SNPATYTGAF TPIRDWFAGL PEAKARGYQP GRFSFNVKGG RCEACQGDGV IKIEMHFLPD
VYVTCDVCHG KRYNRETLDV LFKGKSIADV LDMTVEEGAE FFSAVPAVRD KLETLVKVGL
GYIKVGQQAT TLSGGEAQRV KLAKELSRRA TGRTLYILDE PTTGLHFHDV AKLLEVLHEL
VEQGNTVVVI EHNLEVIKTA DWVIDLGPEG GDGGGEIVAV GRPEDIVQEK RSYTGQFLKE
LLERRPKRSS QAAE
