UVRA_CHLPN
ID UVRA_CHLPN Reviewed; 1826 AA.
AC Q9Z985; Q9JQK9; Q9JSJ5;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=UvrABC system protein A;
DE Short=UvrA protein;
DE AltName: Full=Excinuclease ABC subunit A;
GN Name=uvrA; OrderedLocusNames=CPn_0096, CP_0678, CpB0096;
OS Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC Chlamydia/Chlamydophila group; Chlamydia.
OX NCBI_TaxID=83558;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CWL029;
RX PubMed=10192388; DOI=10.1038/7716;
RA Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL Nat. Genet. 21:385-389(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AR39;
RX PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA Salzberg S.L., Eisen J.A., Fraser C.M.;
RT "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT AR39.";
RL Nucleic Acids Res. 28:1397-1406(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J138;
RX PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT Japan and CWL029 from USA.";
RL Nucleic Acids Res. 28:2311-2314(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TW-183;
RA Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT other Chlamydia strains based on whole genome sequence analysis.";
RL Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000305}.
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DR EMBL; AE001363; AAD18249.1; -; Genomic_DNA.
DR EMBL; AE002161; AAF38489.1; -; Genomic_DNA.
DR EMBL; BA000008; BAA98306.1; -; Genomic_DNA.
DR EMBL; AE009440; AAP98029.1; -; Genomic_DNA.
DR PIR; D72120; D72120.
DR PIR; H86502; H86502.
DR RefSeq; NP_224304.1; NC_000922.1.
DR RefSeq; WP_010882746.1; NZ_LN847257.1.
DR AlphaFoldDB; Q9Z985; -.
DR SMR; Q9Z985; -.
DR STRING; 115711.CP_0678; -.
DR EnsemblBacteria; AAD18249; AAD18249; CPn_0096.
DR EnsemblBacteria; AAF38489; AAF38489; CP_0678.
DR GeneID; 45050141; -.
DR KEGG; cpa:CP_0678; -.
DR KEGG; cpj:uvrA; -.
DR KEGG; cpn:CPn_0096; -.
DR KEGG; cpt:CpB0096; -.
DR PATRIC; fig|115713.3.peg.109; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_3_1_0; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000000583; Chromosome.
DR Proteomes; UP000000801; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-KW.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 5.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 2.
DR SUPFAM; SSF52540; SSF52540; 4.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..1826
FT /note="UvrABC system protein A"
FT /id="PRO_0000093043"
FT DOMAIN 1..581
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 594..909
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1503..1814
FT /note="ABC transporter 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT ZN_FING 721..744
FT /note="C4-type"
FT ZN_FING 1623..1649
FT /note="C4-type"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 626..633
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 966..973
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1536..1543
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 559
FT /note="V -> G (in Ref. 3; BAA98306)"
FT /evidence="ECO:0000305"
FT CONFLICT 1046
FT /note="K -> E (in Ref. 3; BAA98306)"
FT /evidence="ECO:0000305"
FT CONFLICT 1066..1086
FT /note="TTPQTIIDSLLKSYKDDYVTI -> IHLRPSSIATQSYNDELTSLL (in
FT Ref. 3; BAA98306)"
FT /evidence="ECO:0000305"
FT CONFLICT 1094
FT /note="S -> A (in Ref. 3; BAA98306)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1826 AA; 201696 MW; F28CD43D03B12554 CRC64;
MKSLPVYVSG IKVRNLKNVS IHFNSEEIVL LTGVSGSGKS SIAFDTLYAA GRKRYISTLP
TFFATTITTL PNPKVEEIHG LSPTIAIKQN HFSHYSHATV GSTTELFSHL ALLFTLEGQA
RDPKTKEVLD LYSKEKVLST IMELSEGVQI SILAPLLRKD IAAIHEYAQQ GFTKVRCNGT
IHPIYSFLTS GIPEDCSVDI VIDTLIKSEN NIARLKVSLF TALEFGEGHC SVLSDEELMT
FSTKQQIDDV TYTPLTQQLF SPHALESRCS LCQGSGIFIS IDNPLLIDEN LSIKENCCSF
AGNCSSYLYH TIYQALADAL NFNLETPWKD LSPEIQNIFL RGKNNLVLPV RLFDQTLGKK
NLTYKVWRGV LNDIGDKVRY TTKPSRYLSK GMSAHSCSLC KGTGLGDYAS VATWEGKTFT
EFQQMSLNNW HVFFSKVKSP SLSIQEILQG LKQRLSFLID LGLGYLTPNR ALATLSGGEQ
ERTAIAKHLG GELFGITYIL DEPSIGLHPQ DTEKLIGVIK KLRDQGNTVI LVEHEERMIS
LADRIIDIGP GAGIFGGEVL FNGKPEDFLM NSSSLTAKYL RQELTIPIPE SREAPTSWLL
LTEATIHNLK NLSIRLPLAR LIGVTGVSGS GKSSLINNTL VPAIESFLKQ ENPKNLHFEW
GCIGRLIHIT RDLPGRSQRS IPLTYIKAFD DIRELFASQP RSLRQGLTKA HFSFNQPQGA
CIQCQGLGTM TISDDDTPIP CSECQGKRYH SEVLEILYEG KNIADILDMT AYEAEKFFIS
HPKIHEKIHA LCSLRLDYLP LGRPLSTLSG GEIQRLKLAH ELLFASPKQT LYVLDEPTTG
LHTHDIQALI EVLLSLTYLG HTVLVIEHNM HVVKVCDYVL ELGPEGGDLG GYLLASCTPK
DLIQLNTPTA KALAPYIEGS LDIPVVKSEP PSSPKSCDIL IKDAYQNNLK HIDLALPRNS
LIAIAGPGAS GKHSLVFDIL YASGNIAYAE LFPPYIRQGL LKETPLPSVG EVKGLSPVIS
VRKCSSSNRS YHTIASALGL SNGLEKLFAI LGEPFSPLTE EKLSKTTPQT IIDSLLKSYK
DDYVTITSPI PLGSDLEIFL QEKQKEGFIK LYSEGNLYDL DERLPLNLIE PAIVIQHTKV
SPKNSSSLLS AISVAFSLSS EIWIYISQKK QRKLSYSLGW KDKKGRLYPE ITHQLLSSDH
PEGRCLTCGG RGEILKISLE EHKEKIAHYT PLEFFSLFFP KSYMKPVQKL LKDENASQPL
KLLTTKEFLN FCRGSSEFPG MNALLMEQLD TESDSPLIKP LLALTSCPAC KGSGLNDYAN
YVRINNTSLL DIYQEDATFL ESFLNTIGTD DTRSIIQDLM NRLTFISKVG LSYITLGQRQ
DTLSDGENYR LHLAKKISIN LTNIVYLFEE PLSGLHPQDL PTIVQLLKEL VANNNTVIAT
DRSCSLIPHA DHAIFLGPGS GPQGGFLMDS DTEVCPSVDL HANVPQTEVC PKAPLSISKA
NHTRGSDRTL KVNLSIHHIQ NLKVSAPLHA LVAIGGVSGS GKTSLLLEGF KKQAELLIAK
GTTTFSDLVV IDSHPIASSQ RSDISTYFDI APSLRAFYAS LTQAKALNIS STMFSTNTKQ
GQCSDCQGLG YQWIDRAFYA LEKRPCPTCS GFRIQPLAQE VLYEGKHFGE LLHTPIETVA
LRFPFIKKIQ KPLKALLDIG LGYLPIGQKL SSLSVSEKTA LKTAYFLYQT PETPTLFLID
ELFSSLDPIK KQHLPEKLRS LINSGHSVIY IDHDVKLLKS ADYLIEIGPG SGKQGGKLLF
SGSPKDIYAS KDSLLKKYIC NEELDS
