UVRA_CLOTE
ID UVRA_CLOTE Reviewed; 940 AA.
AC Q890X9;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 30-AUG-2005, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=CTC_02503;
OS Clostridium tetani (strain Massachusetts / E88).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=212717;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88;
RX PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAO36966.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AE015927; AAO36966.1; ALT_INIT; Genomic_DNA.
DR RefSeq; WP_035124811.1; NC_004557.1.
DR AlphaFoldDB; Q890X9; -.
DR SMR; Q890X9; -.
DR STRING; 212717.CTC_02503; -.
DR EnsemblBacteria; AAO36966; AAO36966; CTC_02503.
DR GeneID; 64180042; -.
DR KEGG; ctc:CTC_02503; -.
DR HOGENOM; CLU_001370_0_2_9; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000001412; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..940
FT /note="UvrABC system protein A"
FT /id="PRO_0000093047"
FT DOMAIN 309..589
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 609..937
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 252..279
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 740..766
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 641..648
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 940 AA; 105037 MW; 5EF5444326D91FF3 CRC64;
MRDKIVVKGA KVHNLKNVDL QIPRDKFVVF TGLSGSGKSS LAFDTLYAEG QRRYVESLSA
YARQFLGQMD KPDVEYIEGL SPAISIDQKT TSKNPRSTVG TVTEIYDYLR LLYARVGKPH
CPKCGKEIQQ QTVDQMIDKI LELPERTRIQ VLAPIIKGRK GEHIKVIENI IKGGYVRARI
DGEIIDLQEE SVKLEKNKKH TIEAVIDRII IKSDIRSRLA DSIEIALKLS EGVVIINVID
KEDILFSENF ACIDCGISID EISPRLFSFN SPFGKCDYCD GLGTLLEIDE KLVIPNKSKS
ILEGGILPWA NTVTNEDSWT FSILKALSKK YNFSLNTPIG ELDEEIYNML LYGIKGERIK
VRYKKDGRAV DFNHTFEGLM NTLKRRYMET NSNYMKDNIE NYMSDNFCPK CKGARLKPEA
LAVTLGEKNI FEFCKMSIRE ELRFLSELML SNKNKIISNQ ILKEIESRLQ FLIDVGLDYL
DLARMAGTLS GGEAQRIRLA TQIGSSLVGV LYILDEPSIG LHQRDNDRLI ATLKRLRDLG
NTLIVVEHDE DTMRAADYIV DIGPGAGEHG GEIVAAGDLK TVMETEGSLT GQYLVGKKKI
DIPINRRKSN GKSIIVKEAK ENNLKNVDVE FPLGTFTCIT GVSGSGKSTL INEILYKGLN
KKLNNSKEHP GLHKEILGIE NIDKIINIDQ SPIGRTPRSN PATYTGVFDG IREVFSNTTE
SKMRGYKPGR FSFNVKGGRC EACKGDGIIK IEMQFLSDVY VPCEICKGKR YNRETLEVKY
KNKNISEILD MTVEESVDFF KNIPKIKNKL QTLMDVGLGY VRLGQPSTQL SGGEAQRIKL
ASELSKRSTG KTLYILDEPT TGLHIDDVNR LISIIQRLVD GGNTAIIIEH NLDVIKSADY
IIDLGPEGGA KGGEVIGIGT PEEISVNIDS YTGHYLKKML
