UVRA_HELPJ
ID UVRA_HELPJ Reviewed; 941 AA.
AC Q9ZLD6;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=jhp_0644;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE001439; AAD06222.1; -; Genomic_DNA.
DR PIR; H71906; H71906.
DR AlphaFoldDB; Q9ZLD6; -.
DR SMR; Q9ZLD6; -.
DR STRING; 85963.jhp_0644; -.
DR EnsemblBacteria; AAD06222; AAD06222; jhp_0644.
DR KEGG; hpj:jhp_0644; -.
DR eggNOG; COG0178; Bacteria.
DR OMA; PFEGIIP; -.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..941
FT /note="UvrABC system protein A"
FT /id="PRO_0000093055"
FT DOMAIN 316..585
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 605..937
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 260..287
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 737..763
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 37..44
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 637..644
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 941 AA; 104748 MW; 47636DE13BCB3E40 CRC64;
MQHKTIMDKI IIQGARENNL KNIFLEIPKN QFVVFTGLSG SGKSTLAFDT LYAEGQRRYL
ESLSSYARQF LDKVGKPNVD KIEGLTPAIA IDQKTTSKNP RSTVGTITEI YDYLRLLFAR
VGEQFCPTCL EPISSMSASD IISQICHLEE NSKIIILAPI IKDKKGSFND KLESLRLKGY
VRAFVDGVMV RLDEEIHLHK TKKHTIEAVV DRVVINSENA SRIASAVEKA LKESYGELEV
EILQDNAPSI RKHYSEHKAC FKCKMSFEEL EPLSFSFNSP KGACESCLGL GTKFSLDISK
ILDPNTPLNQ GAIKVIFGYN RSYYAQMFEG FCTYNGIDSA LCFNELNKEQ QDALLYGNGT
EISFHFKNSP LKRPWKGIIQ IAYDMFKEQK DLSDYMSEKT CSSCNGHRLK ASSLSVQVAG
LKMADFLTKP IEEVYHFFND PTHFNYLNEQ EKKIAEPILK EILERVFFLY DVGLGYLTLG
RDARTISGGE SQRIRIASQI GSGLTGVLYV LDEPSIGLHE KDTLKLINTL RNLQKKGNTL
IVVEHDKETI KHADFVVDIG PKAGRHGGEV VFSGSVKDLL QNNHSTALYL NGTKKIERPK
FEPPKEKHFL EIKNVNINNI KNLSVQIPLK QLVCITGVSG SGKSSLILQT LLPTAQTLLN
HAKKNQSLNG VEIVGLEYLD KVIYLDQAPI GKTPRSNPAT YTGVMDEIRI LFAEQKEAKI
LGYSTSRFSF NVKGGRCEKC QGDGDIKIEM HFLPDVLVQC DSCKGAKYNP QTLEIKVKGK
SIADVLNMSV EEAYEFFAKF PKIAVKLKTL IDVGLGYITL GQNATTLSGG EAQRIKLAKE
LSKKDTGKTL YILDEPTTGL HFEDVNHLLQ VLHSLVALGN SMLVIEHNLD IIKNADYIID
MGPDGGDKGG KVIASGTPLE VAQNCEKTQS YTGKFLALEL K
