UVRA_LACLA
ID UVRA_LACLA Reviewed; 940 AA.
AC Q9CEL9;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=LL1818;
GN ORFNames=L0256;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE005176; AAK05916.1; -; Genomic_DNA.
DR PIR; B86852; B86852.
DR RefSeq; NP_267975.1; NC_002662.1.
DR RefSeq; WP_003130311.1; NC_002662.1.
DR AlphaFoldDB; Q9CEL9; -.
DR SMR; Q9CEL9; -.
DR STRING; 272623.L0256; -.
DR PaxDb; Q9CEL9; -.
DR PRIDE; Q9CEL9; -.
DR EnsemblBacteria; AAK05916; AAK05916; L0256.
DR KEGG; lla:L0256; -.
DR PATRIC; fig|272623.7.peg.1948; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_9; -.
DR OMA; PFEGIIP; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 3.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..940
FT /note="UvrABC system protein A"
FT /id="PRO_0000093056"
FT DOMAIN 309..586
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 606..935
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 252..279
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 738..764
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 639..646
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 940 AA; 104301 MW; EADA755820963F65 CRC64;
MPQDKIVIHG AREHNLKNID VEIPRDKLVV VTGVSGSGKS SLAFETLYAE GQRRYVESLS
AYARQFLGNM DKPDVDSIDG LSPAISIDQK TTSKNPRSTV GTVTEINDYL RLLYARVGTP
YCVNGHGKIS AQSVEEIVEQ ILELPEKTRL QILAPVVRTK KGTHVKMFER IQKDGYVRVR
VDGEVYDISE VPELDKNKKH NIEIVIDRIV VKEGIRSRLF DSVEAALHQA EGYVIVDKMD
GSELLFSEFY ACPVCGFTVP ELEPRLFSFN APFGSCPDCD GLGVKLEPDV DLLIPDTSKT
LREGAIIYWY GKASTYYPAL LEQAMEQFGI DLDRPWEKLS EKEQQIVLYG NGDKLFHFLH
EGDFGLRDQD MTFVGVIPNL WRRYRSGMSE SAREMARSYM TELTCTTCHG YRLNDQALSV
KVGEKNIAEF SILSIGDTLD YVKSLVLSAN NEIIAKPILK EIKDRLTFLK NVGLDYLTLS
RSSGTLSGGE SQRIRLATQI GSNLSGVLYI LDEPSIGLHQ RDNDRLIESL QKMRDLGNTL
IVVEHDEDTM MAADWLIDVG PGAGDLGGEI IASGTPKQVM KNKKSLTGQY LSGKRAIPVP
EKRRAIDKKK MVKITGASEN NLQNLDVEFP MGVMTAVTGV SGSGKSTLVN SILKKSLAQK
LNHNSEKPGK HKKITGYEGI ERLIDIDQSP IGRTPRSNPA TYTSVFDDIR DLFANTNEAK
IRGYKKGRFS FNVKGGRCEA CSGDGIIKIE MHFLPDVYVP CEVCHGRRYN SETLEVHYKG
KNISEVLDMR VSDGLEFFRH IPKIERKLQT IVDVGLGYVT LGQSATTLSG GEAQRMKLAS
ELQKRSNGKA FYILDEPTTG LHSEDIATLI QVLDRLVEQG NTIVVIEHNL DVIKTADYII
DLGPEGGAGG GTILAKGRPE EVAKVADSYT GQYLKAKLEK
