ID   UVRA_LEPIC              Reviewed;         948 AA.
AC   Q72RM8;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE            Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN   Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=LIC_11717;
OS   Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni
OS   (strain Fiocruz L1-130).
OC   Bacteria; Spirochaetes; Leptospirales; Leptospiraceae; Leptospira.
OX   NCBI_TaxID=267671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fiocruz L1-130;
RX   PubMed=15028702; DOI=10.1128/jb.186.7.2164-2172.2004;
RA   Nascimento A.L.T.O., Ko A.I., Martins E.A.L., Monteiro-Vitorello C.B.,
RA   Ho P.L., Haake D.A., Verjovski-Almeida S., Hartskeerl R.A., Marques M.V.,
RA   Oliveira M.C., Menck C.F.M., Leite L.C.C., Carrer H., Coutinho L.L.,
RA   Degrave W.M., Dellagostin O.A., El-Dorry H., Ferro E.S., Ferro M.I.T.,
RA   Furlan L.R., Gamberini M., Giglioti E.A., Goes-Neto A., Goldman G.H.,
RA   Goldman M.H.S., Harakava R., Jeronimo S.M.B., Junqueira-de-Azevedo I.L.M.,
RA   Kimura E.T., Kuramae E.E., Lemos E.G.M., Lemos M.V.F., Marino C.L.,
RA   Nunes L.R., de Oliveira R.C., Pereira G.G., Reis M.S., Schriefer A.,
RA   Siqueira W.J., Sommer P., Tsai S.M., Simpson A.J.G., Ferro J.A.,
RA   Camargo L.E.A., Kitajima J.P., Setubal J.C., Van Sluys M.A.;
RT   "Comparative genomics of two Leptospira interrogans serovars reveals novel
RT   insights into physiology and pathogenesis.";
RL   J. Bacteriol. 186:2164-2172(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC       A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC       scans DNA for abnormalities. When the presence of a lesion has been
CC       verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC       Rule:MF_00205}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR   EMBL; AE016823; AAS70306.1; -; Genomic_DNA.
DR   RefSeq; WP_001156251.1; NC_005823.1.
DR   AlphaFoldDB; Q72RM8; -.
DR   SMR; Q72RM8; -.
DR   PaxDb; Q72RM8; -.
DR   EnsemblBacteria; AAS70306; AAS70306; LIC_11717.
DR   GeneID; 61141613; -.
DR   KEGG; lic:LIC_11717; -.
DR   HOGENOM; CLU_001370_0_2_12; -.
DR   OMA; PFEGIIP; -.
DR   Proteomes; UP000007037; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00205; UvrA; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   InterPro; IPR041102; UvrA_inter.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   Pfam; PF17760; UvrA_inter; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW   Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..948
FT                   /note="UvrABC system protein A"
FT                   /id="PRO_0000093058"
FT   DOMAIN          307..586
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   DOMAIN          606..934
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         249..277
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         737..763
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         31..38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         638..645
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ   SEQUENCE   948 AA;  105536 MW;  7900372D53C5EF4D CRC64;
     MQEIRIRGAR EHNLKNINVD IPRDQLVVIT GLSGSGKSSL AFDTIYAEGQ RRYVESLSAY
     ARQFLGQMEK PDLDLIEGLS PAISIEQKTT HRNPRSTVGT VTEIYDYLRL LYARVGKPHC
     PECGTPIQSM SIDQITARVL AFPQGSKLQI LAPVISGKKG EHKDVLEKIR KDGFNRVRIN
     GEIRTLEEEI VLKKNFKTSI EIVVDRIVMK EGIRSRLADS VETALKQSEG LVILDDGSKD
     HILSQKMACP NGHDIGFTEL SPRMFSFNSP YGACETCDGL GSLLEFDEDL LVNDPELSLV
     DGCIEAWAGS KSNGFWFMAT LKSLSDSLKF KMNTPWKDLP EKTRQTILYG DKKIKIEYDF
     RGANSHYEFT KEYEGVIPNL QRRYKETKSD SMRQWFESYM TNHPCPSCKG KRLKRESLSV
     KVHNVPVDEF TSYSIEKALN FVQNLKVTGA EEIIAKPILK EIHQRLSFLN DVGVGYLTLE
     RSAGSLSGGE AQRIRLATQI GSRLMGVLYI LDEPSIGLHQ RDNTKLVSTL KNLRDLGNTV
     LVVEHDQETM EESDWLIDMG PGAGVHGGSI VCAGTPAEVS KHKNSLTGKY LSGRLKVPIP
     AKLREGNGSK LQIIGAKENN LKNIDVNIPL GKLVVITGVS GSGKSTLIND ILYNAAAHKV
     MKMKTLAGKH KTIKGFENID KIINIDQSPI GRTPRSNPAT YTGLFTPIRE MFAGLEEAKL
     RGYGPGRFSF NVSGGRCETC EGDGILKIEM HFLPDVYVTC EVCKGKRYNQ ETLEVRYKGK
     NIFDVLEMTV EDANQFFENI PIVKRKLETL LEVGLGYIRL GQPATTFSGG EAQRIKLATE
     LSKRPTGKTL YILDEPTTGL HFEDVRRLSE VLHTLVDRGN SMIVIEHNLD VIKQADWIVD
     MGPEGGDGGG LVIAEGIPKD IAKIKNSYTG QYLKKIFTSS EKISRKTK