UVRA_LISMF
ID UVRA_LISMF Reviewed; 956 AA.
AC Q71WU0;
DT 07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205};
GN OrderedLocusNames=LMOf2365_2461;
OS Listeria monocytogenes serotype 4b (strain F2365).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Listeriaceae; Listeria.
OX NCBI_TaxID=265669;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F2365;
RX PubMed=15115801; DOI=10.1093/nar/gkh562;
RA Nelson K.E., Fouts D.E., Mongodin E.F., Ravel J., DeBoy R.T., Kolonay J.F.,
RA Rasko D.A., Angiuoli S.V., Gill S.R., Paulsen I.T., Peterson J.D.,
RA White O., Nelson W.C., Nierman W.C., Beanan M.J., Brinkac L.M.,
RA Daugherty S.C., Dodson R.J., Durkin A.S., Madupu R., Haft D.H.,
RA Selengut J., Van Aken S.E., Khouri H.M., Fedorova N., Forberger H.A.,
RA Tran B., Kathariou S., Wonderling L.D., Uhlich G.A., Bayles D.O.,
RA Luchansky J.B., Fraser C.M.;
RT "Whole genome comparisons of serotype 4b and 1/2a strains of the food-borne
RT pathogen Listeria monocytogenes reveal new insights into the core genome
RT components of this species.";
RL Nucleic Acids Res. 32:2386-2395(2004).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE017262; AAT05226.1; -; Genomic_DNA.
DR RefSeq; WP_003725420.1; NC_002973.6.
DR AlphaFoldDB; Q71WU0; -.
DR SMR; Q71WU0; -.
DR KEGG; lmf:LMOf2365_2461; -.
DR HOGENOM; CLU_001370_0_2_9; -.
DR OMA; PFEGIIP; -.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..956
FT /note="UvrABC system protein A"
FT /id="PRO_0000093061"
FT DOMAIN 309..587
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 607..936
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 252..279
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 738..764
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 639..646
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 956 AA; 106535 MW; 18BA7D1DFE4127E5 CRC64;
MDKEKIVIQG ARAHNLKNID VEIPRDKLVV MTGLSGSGKS SLAFDTIYAE GQRRYVESLS
AYARQFLGQM DKPDVDLIEG LSPAISIDQK TTSRNPRSTV GTVTEIHDYL RLLYARVGHP
VCPNHGIEIT SQTIEQMVDR VLEYPEKTRI QIMAPIVSGK KGTHKKTIEE IKKEGYVRIR
VDGEIYDIND EIEIEKNKKH SIEIIIDRIV IKEGINTRLY DSIEAALRLA DGYAVVDIMG
DKELLFSEHY ACPYCGFSVG ELEPRMFSFN SPFGACPTCD GLGTKLEVDV DTVIPDRSLS
LNEGAIIPWR PISSQYYPQM LASACKEFGI DMDTPLEKLT KEELDIILNG SKDKEFYFEY
KNDFGMTRET WIPFEGILPN IERRYRETNS DFTRDQMAQY MTDLPCPSCK GYRLKEETLS
VKVNNHHIGQ ISEFSINEAL DFFDGLELSE KETQIAAPIF KEVRARLGFL KNVGLDYLTM
SRAAGTLSGG EAQRIRLATQ IGSRLTGVLY ILDEPSIGLH QRDNDRLIST LQSMRDIGNT
LIVVEHDEDT MMAADYLIDI GPGAGEHGGR IVAAGTPEEV AKNKNSITGD YLSGKKFIPV
PAKRRKGNGL ELEIIGAKAN NLKNVNAKIP LATFSCVTGV SGSGKSSLVN EVLRKALARK
LNRNHAKPGE HKEIKGIENL EKIINIDQSP IGRTPRSNPA TYTGAFDDIR DLFASTNEAK
VRGYKKGRFS FNVKGGRCEA CKGDGIIKIE MHFLPDVYVP CEVCHGKRYN GETLDIRYKG
KNIAEVLEMT VEEGLEYFTN QPRIARKLQT IVDVGLGYIR LGQPATTLSG GEAQRVKLAS
ELHKRSNGKS FYILDEPTTG LHADDIGRLL KVLQRLVEEN GDTVLVIEHN LDVIKQADYL
IDLGPEGGDG GGQIIATGTP EKIARSKKSY TGKYLKPILE RDKERTEERI ATAKKK
