UVRA_MALP2
ID UVRA_MALP2 Reviewed; 952 AA.
AC Q8EUL1;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=MYPE9100;
OS Malacoplasma penetrans (strain HF-2) (Mycoplasma penetrans).
OC Bacteria; Tenericutes; Mycoplasmoidales; Mycoplasmoidaceae; Malacoplasma.
OX NCBI_TaxID=272633;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HF-2;
RX PubMed=12466555; DOI=10.1093/nar/gkf667;
RA Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT "The complete genomic sequence of Mycoplasma penetrans, an intracellular
RT bacterial pathogen in humans.";
RL Nucleic Acids Res. 30:5293-5300(2002).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; BA000026; BAC44701.1; -; Genomic_DNA.
DR RefSeq; WP_011077730.1; NC_004432.1.
DR AlphaFoldDB; Q8EUL1; -.
DR SMR; Q8EUL1; -.
DR STRING; 272633.26454373; -.
DR EnsemblBacteria; BAC44701; BAC44701; BAC44701.
DR KEGG; mpe:MYPE9100; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_14; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000002522; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..952
FT /note="UvrABC system protein A"
FT /id="PRO_0000093065"
FT DOMAIN 315..596
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 616..945
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 258..285
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 747..773
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 648..655
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 952 AA; 106312 MW; 745C0F3996D3DC2E CRC64;
MNNKVNTRDF IVVKGARENN LKNVDIDIPK NKFVVMTGLS GSGKSSLAFD TIYAEGQRRY
LESLSSYARQ FLGGNEKPDV DSIEGLSPAI SIDQKTTSHN PRSTVGTVTE IYDYLRLLFS
RIGKPYCPNG HGLISTLSIK QMIDTVYENK EESKIQILSP IISQEKGTFK NKIEELKRQG
YLRLRIDGNI YSLDDEIELE KTKKHNIDIL IDRIILNNDT VTRSRIYDAI EKSVKEANGK
VIVLVDDKEL FFSQNHACNE CGFSIPELEP RFFSFNSPVG ACKSCNGIGF NFLPDTAKIV
PDPSLSIKEG AIAYFRSVMM TPTMDLKREM SVWKEHDINL DVPFKELSKK EKNIIFYGDE
DIGELKIDVN EQSIYSSSSF LYNNGLVNLI MRRFSETQSE RAREYYEKFM SNLSCPSCNG
QKLSIEALSV KINNKNIIDL TEKNINDLTN FFIELELNET DRNIAHLALK EIVDRLSFLE
NVGLNYLTLS RSASTLSGGE SQRIRLATQI GSSLTGVLYV LDEPSIGLHQ KDNEKLIETL
KKMRDLGNTL IVVEHDEDTI RASDYLIDIG PKAGDFGGEV VAAGTVSEVS ENKKSITAQY
LSGKLKIEVP SKRRHGNGKT IELVGASGNN LKNVTVSFPL NKLIAVTGVS GSGKSTLINE
TLIKGIEKKL TNPFIVPAPF KDIKGLKNVD KIIKVSQDPI GRTPRSNPAT YVSVFDDIRD
LFANTKEAKA RGFQKGRFSF NVSGGRCENC SGDGLIKIEM HFLPDVFVKC ESCNGKKYNQ
ETLQVLYKGK SIYDVLEMSV VEARDFFYEI PEIKRKLDLM VEVGIDYLKL GTSSTHLSGG
EAQRIKLAKY LQKRATGKTI YVLDEPTTGL HIHDIAKLIT VLNRIVDNGD TVIVVEHNLD
LIKCADYVID LGPDGGINGG QLVAYGTPEE IIEKKAVSYT GLFLEKNMYK DK
