ID   UVRA_MYCGE              Reviewed;         952 AA.
AC   P47660; Q49295;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE            Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN   Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=MG421;
OS   Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)
OS   (Mycoplasmoides genitalium).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243273;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=7569993; DOI=10.1126/science.270.5235.397;
RA   Fraser C.M., Gocayne J.D., White O., Adams M.D., Clayton R.A.,
RA   Fleischmann R.D., Bult C.J., Kerlavage A.R., Sutton G.G., Kelley J.M.,
RA   Fritchman J.L., Weidman J.F., Small K.V., Sandusky M., Fuhrmann J.L.,
RA   Nguyen D.T., Utterback T.R., Saudek D.M., Phillips C.A., Merrick J.M.,
RA   Tomb J.-F., Dougherty B.A., Bott K.F., Hu P.-C., Lucier T.S.,
RA   Peterson S.N., Smith H.O., Hutchison C.A. III, Venter J.C.;
RT   "The minimal gene complement of Mycoplasma genitalium.";
RL   Science 270:397-403(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-85.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=8253680; DOI=10.1128/jb.175.24.7918-7930.1993;
RA   Peterson S.N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A survey of the Mycoplasma genitalium genome by using random sequencing.";
RL   J. Bacteriol. 175:7918-7930(1993).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 569-668.
RC   STRAIN=ATCC 33530 / DSM 19775 / NCTC 10195 / G37;
RX   PubMed=1945886; DOI=10.1093/nar/19.21.6027;
RA   Peterson S.N., Schramm N., Hu P.-C., Bott K.F., Hutchison C.A. III;
RT   "A random sequencing approach for placing markers on the physical map of
RT   Mycoplasma genitalium.";
RL   Nucleic Acids Res. 19:6027-6031(1991).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC       A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC       scans DNA for abnormalities. When the presence of a lesion has been
CC       verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC       Rule:MF_00205}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC71645.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAD12454.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; L43967; AAC71645.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U02172; AAD12454.1; ALT_INIT; Genomic_DNA.
DR   EMBL; X61514; CAA43728.1; -; Genomic_DNA.
DR   PIR; T09750; T09750.
DR   AlphaFoldDB; P47660; -.
DR   SMR; P47660; -.
DR   STRING; 243273.MG_421; -.
DR   PRIDE; P47660; -.
DR   EnsemblBacteria; AAC71645; AAC71645; MG_421.
DR   KEGG; mge:MG_421; -.
DR   eggNOG; COG0178; Bacteria.
DR   HOGENOM; CLU_001370_0_2_14; -.
DR   Proteomes; UP000000807; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00205; UvrA; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   InterPro; IPR041102; UvrA_inter.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   Pfam; PF17760; UvrA_inter; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW   Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW   Repeat; SOS response; Zinc; Zinc-finger.
FT   CHAIN           1..952
FT                   /note="UvrABC system protein A"
FT                   /id="PRO_0000093064"
FT   DOMAIN          316..595
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   DOMAIN          615..944
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         259..286
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         746..772
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         38..45
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         647..654
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ   SEQUENCE   952 AA;  106334 MW;  FA59421690F3EB94 CRC64;
     MKPEWKNNDF IRVKGARENN LKNINIDIPK NQFVVITGLS GSGKSSLAFN TIYAEGRRRY
     LESLSSYARQ FLGNSDKPDV DLIEGLSPAI SIDQKTTSHN PRSTMGTVTE IYDYLRLLWA
     RIGTPYCPNG HGSIQTQTIN QIANQIFDLP NKSKVQLLAP TVKNQRGIFT NEFIKYKQLG
     FLRVLVDGQI YTLDDEIKLD KNTKHNISVV IDRIIINKDN QTYSRIVDSI ETIDRLTNGK
     IEVLKEDGTI LNFSKNHGCD KCGFSISELE PRLFSFNSPL GSCSYCKGLG FSYEPDVDKI
     IADSKLSINQ GAIDIFKNIV HGTSLDWQRF LSLVNHYKIP LDKPIEQLDK SQLNLILEGS
     DEPIEIKTIS NSGAKNIRFE HYEGIANLIK RRHLETNSQV SREWYSAYMS EITCKKCHGK
     KLIKDALSVK LGGIDIISFT ELSIDKSIDF LLKLELNDEQ KKIGELALKE IINRLSFLKN
     VGLDYLNLAR RASTLSGGEA QRIRLATQIG SQLTGVLYVM DEPSIGLHQK DNMRLIKTMM
     VMRDLGNTLL VVEHDSETML AADYLIDIGP KAGNEGGELV ACGTPLQVME NSNSITGQYL
     SGKKQISIPK NRHSGNGKTI IIKGAKVNNL KNINVTIPLN KLVLITGVSG SGKSSLINQT
     LVPALERILY RKGVKKDTYK EIIGANNIDK IIVVSQDPIG RTPRSNPATY ISVFDDIRDL
     FANTKEAKAR GYTNSRFSFN VPGGRCDKCF GDGVIRIEMH FLPDVYVKCE VCNGKKYNSQ
     TLEIKYLGKS IFDVLQMSCK EAYEFFKAIP NISRKLRLLC DVGLEYLQLG INVTFLSGGE
     AQRIKLSKFL QKKSTGKTLF VLDEPSTGLH LEDINKLLTI IQRIIKNGDT VVVIEHNLDI
     IKVADYIIDL GPEGGDNGGQ IVAQGTPEQL INQVNKSYTA QYLSKILKPD SI