UVRA_MYCLE
ID UVRA_MYCLE Reviewed; 969 AA.
AC Q9CC24;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=ML1392;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AL583921; CAC31773.1; -; Genomic_DNA.
DR PIR; B87083; B87083.
DR RefSeq; NP_301990.1; NC_002677.1.
DR RefSeq; WP_010908311.1; NC_002677.1.
DR AlphaFoldDB; Q9CC24; -.
DR SMR; Q9CC24; -.
DR STRING; 272631.ML1392; -.
DR EnsemblBacteria; CAC31773; CAC31773; CAC31773.
DR KEGG; mle:ML1392; -.
DR PATRIC; fig|272631.5.peg.2590; -.
DR Leproma; ML1392; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_11; -.
DR OMA; PFEGIIP; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..969
FT /note="UvrABC system protein A"
FT /id="PRO_0000093069"
FT DOMAIN 316..599
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 619..948
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 258..286
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 751..777
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 652..659
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 969 AA; 106378 MW; 6668141833C53DB5 CRC64;
MADRLIVKGA REHNLRSVDL DLPRDSLIVF TGLSGSGKSS LAFDTIFAEG QRRYVESLSA
YARQFLGQMD KPDVDFIEGL SPAVSIDQKS TNRNPRSTVG TITEVYDYLR LLYARAGTPH
CPICGEQISR QTPQQIVDQV LVLPEGTRFL VLAPVVRTRK GEFADLFDKL NAQGYSRVRV
DDVVYPLSDP PKLKKQEKHD IEVVVDRLTV KIAAKQRLTD SVETALNLAD GIVVLEFPDD
HDERGHPREQ CFSEKLACPN GHPLAVDDLE PRSFSFNSPY GACPECVGLG IRKEIDSDLV
VPDPDRTLAE GAVAPWSAGR TAEYFTRMMA GLGEKLGFDV DTPWRKLPAK ARKAILEGSD
HQVHVQYHNR YGRPRSYYVD FEGVLTFLQR KMEQTESEQM KERYEGFMRN IPCPVCQGTR
LKPEILAVTL AAGERGAKSI AEVCELSIAD CSAFLNALIL GVREQAIAGQ VLKEIQSRLG
FLLDVGLEYL SLSRAAATLS GGEAQRIRLA TQIGSGLVGV LYVLDEPSIG LHQRDNRRLI
ETLTRLRALG NTLIVVEHDE DTIAHADWVV DIGPGAGEHG GQIVHNGTYR ELLANKDSIT
GAYLSGRESI ATPTRRRSVD RKRELTVVGA REHNLRGIDV SFPLGVLTSV TGVSGSGKST
LVNDILAAVL ANRLNGARQV PGRHTRVTGL EHLDKLVRVD QSPIGRTPRS NPATYTGVFD
KIRILFAATT EAKVRGYQPG RFSFNVKGGR CEACTGDGTI KIEMNFLPDV YVPCEVCQGA
RYNRETLEVH YKGKAISEVL DMSIEEAAEF FEPIIGINRY LRTLVDVGLG YVRLGQPAPT
LSGGEAQRVK LASELQKRST GRTIYILDEP TTGLHFDDIR KLLNVINGLV DKDNTVIVIE
HNLDVIKTSD WIVDMGPEGG AQGGTVVAEG TPEDVAAVPE SYTGKFLAEV VGAGCAPART
PRRRRTVTA
