UVRA_MYCPN
ID UVRA_MYCPN Reviewed; 948 AA.
AC P75176;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1997, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=MPN_619;
GN ORFNames=MP223;
OS Mycoplasma pneumoniae (strain ATCC 29342 / M129) (Mycoplasmoides
OS pneumoniae).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX NCBI_TaxID=272634;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29342 / M129;
RX PubMed=8948633; DOI=10.1093/nar/24.22.4420;
RA Himmelreich R., Hilbert H., Plagens H., Pirkl E., Li B.-C., Herrmann R.;
RT "Complete sequence analysis of the genome of the bacterium Mycoplasma
RT pneumoniae.";
RL Nucleic Acids Res. 24:4420-4449(1996).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; U00089; AAB95871.1; -; Genomic_DNA.
DR PIR; S73549; S73549.
DR RefSeq; NP_110308.1; NC_000912.1.
DR RefSeq; WP_010874976.1; NC_000912.1.
DR AlphaFoldDB; P75176; -.
DR SMR; P75176; -.
DR IntAct; P75176; 3.
DR STRING; 272634.MPN_619; -.
DR EnsemblBacteria; AAB95871; AAB95871; MPN_619.
DR KEGG; mpn:MPN_619; -.
DR PATRIC; fig|272634.6.peg.683; -.
DR HOGENOM; CLU_001370_0_2_14; -.
DR OMA; PFEGIIP; -.
DR BioCyc; MPNE272634:G1GJ3-999-MON; -.
DR Proteomes; UP000000808; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 3.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..948
FT /note="UvrABC system protein A"
FT /id="PRO_0000093066"
FT DOMAIN 316..595
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 615..944
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 259..286
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 746..772
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 38..45
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 647..654
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 948 AA; 105426 MW; 4466DE773D3B370C CRC64;
MKPELKTNDF IRVKGARENN LKNVNIDIPK NQFVVITGLS GSGKSSLAFN TIYAEGRRRY
LESLSSYARQ FLGNSDKPDV DSIEGLSPAI SIDQKTTSHN PRSTVGTVTE IYDYLRLLWA
RIGIPFCPNG HGAIQTQTVN QIANQIFNLP VKSRIQILAP TIKNQRGTFA NEFAKYQQLG
FLRVWVDGQV YTLDEEIKLD KNTKHNLSVV VDRIVINQDK QTLGRIVDAI EGVIKLTEGR
IEVLLEDGKI LSFNKNHGCD QCGFSISELE PRLFSFNSPL GSCEYCKGLG FSYEPDVEKI
IPNPLLSINE GGIDIFKNIV HGTSLDWQRF LSLINHYQIP LDQPLGQMDT DLVRMILEGS
DEPIEIKTVS NSGAKNVRFE HYEGVAHLIK RRHLETSSQA SREWYSAYMS EITCKKCQGK
KLTTNSLSVK LGGLDIISFT ELSIDKAIEF LLQIELNQEQ KKIGELALKE IINRLSFLKN
VGLEYLNLAR RASTLSGGEA QRIRLATQIG SQLTGVLYVL DEPSIGLHQK DNDRLINTMM
VMRDLGNTLL VVEHDSETML AADYLIDIGP KAGNQGGEVV AAGTPLEVME NPDSLTGQYL
SGKKQIEVPK TRHAGNGRTL TLKGAKGNNL KNINVTIPLN KLVLVTGVSG SGKSTLINQT
LVPILERLVN YKNVKPAPYK EIIGVNHIDK VVVVSQDPIG RTPRSNPATY VSVFDDIREL
FANTKEAKAR GYTNSRFSFN VAGGRCDKCF GDGVIRIEMH FLPDVYVTCE MCDGKKYNPQ
TLEVKYLGKS IFDVLQMSCQ EAYDFFKAIP NIARKLKLLC DVGLEYLQLG LNVTFLSGGE
AQRIKLAKFL QKKATGKTLY VLDEPSTGLH IEDINKLLTV IQRIIKNGDS VIIIEHNLDI
IKMADYIIDL GPEGGEKGGQ IIAQGTPEQL LNQVDKSYTA QYLAKILK
