UVRA_MYCPU
ID UVRA_MYCPU Reviewed; 944 AA.
AC Q98PL2;
DT 07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=MYPU_7100;
OS Mycoplasmopsis pulmonis (strain UAB CTIP) (Mycoplasma pulmonis).
OC Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX NCBI_TaxID=272635;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UAB CTIP;
RX PubMed=11353084; DOI=10.1093/nar/29.10.2145;
RA Chambaud I., Heilig R., Ferris S., Barbe V., Samson D., Galisson F.,
RA Moszer I., Dybvig K., Wroblewski H., Viari A., Rocha E.P.C., Blanchard A.;
RT "The complete genome sequence of the murine respiratory pathogen Mycoplasma
RT pulmonis.";
RL Nucleic Acids Res. 29:2145-2153(2001).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AL445565; CAC13883.1; -; Genomic_DNA.
DR PIR; F90600; F90600.
DR RefSeq; WP_010925511.1; NC_002771.1.
DR AlphaFoldDB; Q98PL2; -.
DR SMR; Q98PL2; -.
DR STRING; 272635.MYPU_7100; -.
DR EnsemblBacteria; CAC13883; CAC13883; CAC13883.
DR KEGG; mpu:MYPU_7100; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_14; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR BioCyc; MPUL272635:G1GT6-723-MON; -.
DR Proteomes; UP000000528; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..944
FT /note="UvrABC system protein A"
FT /id="PRO_0000093067"
FT DOMAIN 1..242
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 359..597
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 610..935
FT /note="ABC transporter 3"
FT ZN_FING 256..283
FT /note="C4-type; degenerate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 744..770
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 643..650
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 944 AA; 105298 MW; 5EE52AC2B5F9E507 CRC64;
MSKVDFLHIK GARENNLKNV ELTIPKNKLV IFTGLSGSGK SSLAFNTIYE EGRRRYVDSL
SSYARQFLGG TSKPDVDSIE GLSPAISIEQ KTTHNNPRST VGTVTEIYDY LRLLYARIGK
PFCPKHKIKI EGKTTKLIIE GIVDFPKNSK LIILSPVVEL EKGTHQKLIA KLKTEGFLRL
KINNEIVSLS DDKEINLDKN KRHSIDIVVD RIVLNEEKKL EISEAISIAL EYGKGIVKVE
NVETGEIKIF SSNHSCPKGD FEMPKIETRL FSFNSPYGMC QNCKGLGVQL RGDYNLLVPD
QNLSISEGAI KIFESTVNSS NQEWQEFEAL LNYYGIDKNI PMRKLSESDR QIIKYGSKEE
IDYIIKSQSN KFKRTKRIEG IIDKVERKYL ETSSEGIRTW IKRYMSEFIC NMCKGSRLNE
HALAVKINGL NIWEISSLSI NDVYEQSINL NLSDYEREIT TLLISELTSR LSFLVDVGLD
YLTLNRMAES LSGGEAQRIR LATQIGSNLT GVLYVLDEPS IGLHQKDNER LIKTLRKMVE
IGNTLIVVEH DEDTMRASDF IVDIGPKAGS HGGEIVALGS VEDIIKNPIS ITGKYLSGEW
QNATPKSRRS GSGNVIKITG ASQNNIKKLD FKIPLGKFIG VTGVSGSGKS TLINQVLVNA
IEKGIARDFS HDKNKNYEKI EGLLYIDKLI KISQSPIGRT PRSNPATYSS LFDDIREIFS
NVPEAKARGY QKGRFSFNVP GGRCEKCSGD GSIKIEMFFL PNVYITCDHC DGKRYNEETL
QIKYRSKSIS DVLDMTVSDA LAFFENRLIV KNKLQTLEDV GLGYIKLGQS STTLSGGEAQ
RVKLASHLLK KSTGKTLYVL DEPTTGLHSH DVSLLLKVLN RLVDKGDTVI VIEHNLDVIK
NCDYLIDLGP GGGVNGGKII ATGTPEQVAQ IEKSYTGEFL KRVL
