UVRA_OCEIH
ID UVRA_OCEIH Reviewed; 958 AA.
AC Q8ENJ6;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=OB2487;
OS Oceanobacillus iheyensis (strain DSM 14371 / CIP 107618 / JCM 11309 / KCTC
OS 3954 / HTE831).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Oceanobacillus.
OX NCBI_TaxID=221109;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 14371 / CIP 107618 / JCM 11309 / KCTC 3954 / HTE831;
RX PubMed=12235376; DOI=10.1093/nar/gkf526;
RA Takami H., Takaki Y., Uchiyama I.;
RT "Genome sequence of Oceanobacillus iheyensis isolated from the Iheya Ridge
RT and its unexpected adaptive capabilities to extreme environments.";
RL Nucleic Acids Res. 30:3927-3935(2002).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; BA000028; BAC14443.1; -; Genomic_DNA.
DR RefSeq; WP_011066880.1; NC_004193.1.
DR AlphaFoldDB; Q8ENJ6; -.
DR SMR; Q8ENJ6; -.
DR STRING; 221109.22778173; -.
DR PRIDE; Q8ENJ6; -.
DR EnsemblBacteria; BAC14443; BAC14443; BAC14443.
DR KEGG; oih:OB2487; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_0_9; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR PhylomeDB; Q8ENJ6; -.
DR Proteomes; UP000000822; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..958
FT /note="UvrABC system protein A"
FT /id="PRO_0000093074"
FT DOMAIN 1..232
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 315..593
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 604..935
FT /note="ABC transporter 3"
FT ZN_FING 252..279
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 738..764
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 639..646
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 958 AA; 106874 MW; 9A532911BAC27ED6 CRC64;
MQSKSIKIQG ARTHNLKDID IDIPKNKLVV LTGLSGSGKS SLAFDTIYAE GQRRYVESLS
SYARQFLGQM DKPDVDVIEG LSPAISIDQK TTSKNPRSTV GTVTEIYDYL RLLYARVGRP
TCPNHGIEIS SQTVQQMVDR ILEYPERTKL QILAPVVSGR KGEHVKILEN LKQEGYVRIR
VDNEMREVTD DIQLEKNKKH SIEVVIDRIV VKDGVASRLS DSIETALKLG EGNIIVDVIG
EEELTFSENH ACPICGFSIG ELEPRLFSFN SPFGACPSCD GLGTKLEVDI DLVIPDWEKT
LNENAIAPWE PISSQYYPQL LKSVCNHFGI DMDIPVKEIP QQQMDIILQG SGKEKIKFEY
ENDFGSIRRS EAPFEGVLKN VARRYRETSS DFIRETLEKY MAQKNCPTCK GHRLKKEALA
VLINGKHISN VTDYSIVESI QLFQQLDLTE KEQQIARLIL KEIDNRLEFL NNVGLDYLTL
SRTAGTLSGG EAQRIRLATQ IGSALTGVLY VLDEPSIGLH QRDNDRLIDT LKRMRDLDNT
LIVVEHDEDT MLAADWLVDI GPGAGEHGGE IVASDTPQNV MKNEQSLTGK YLSGKEFIPL
PTKRRKPNKR KIEVMGASEN NLKNVSAKIP IGLMTVVTGV SGSGKSTLVN EIVYKSLAKS
LYKGKVKPGK HKKIKGIEHI DKVIDIDQSP IGRTPRSNPA TYTGVFDDIR DVFAQTNEAK
VRGYKKGRFS FNVKGGRCEA CRGDGILKIE MHFLPDVYVP CEVCHGARYN RETLEVKYKG
KNISEVLELR IEEALEFFSA IPKIKRKLQT VYDVGLGYIR LGQPATTLSG GEAQRVKLAS
ELHKRSTGKS FYILDEPTTG LHVDDIRRLL SVLQRIADNG DSVLIIEHNL DVIKSADHII
DLGPEGGDRG GQIIATGTPE QIAEQQDVSY TGKYLSPVLD RDKQRMEETL EAKTVSRS
