UVRA_RHILO
ID UVRA_RHILO Reviewed; 973 AA.
AC Q98M36;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=mlr0750;
OS Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)
OS (Mesorhizobium loti (strain MAFF 303099)).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Phyllobacteriaceae; Mesorhizobium.
OX NCBI_TaxID=266835;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LMG 29417 / CECT 9101 / MAFF 303099;
RX PubMed=11214968; DOI=10.1093/dnares/7.6.331;
RA Kaneko T., Nakamura Y., Sato S., Asamizu E., Kato T., Sasamoto S.,
RA Watanabe A., Idesawa K., Ishikawa A., Kawashima K., Kimura T., Kishida Y.,
RA Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Mochizuki Y.,
RA Nakayama S., Nakazaki N., Shimpo S., Sugimoto M., Takeuchi C., Yamada M.,
RA Tabata S.;
RT "Complete genome structure of the nitrogen-fixing symbiotic bacterium
RT Mesorhizobium loti.";
RL DNA Res. 7:331-338(2000).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; BA000012; BAB48277.1; -; Genomic_DNA.
DR RefSeq; WP_010909632.1; NC_002678.2.
DR AlphaFoldDB; Q98M36; -.
DR SMR; Q98M36; -.
DR STRING; 266835.14021665; -.
DR PRIDE; Q98M36; -.
DR EnsemblBacteria; BAB48277; BAB48277; BAB48277.
DR GeneID; 66683902; -.
DR KEGG; mlo:mlr0750; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_5; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000000552; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..973
FT /note="UvrABC system protein A"
FT /id="PRO_0000093081"
FT DOMAIN 330..609
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 629..958
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 761..787
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 34..41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 662..669
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 973 AA; 107359 MW; 767D7D2DC8220057 CRC64;
MADHKFLSIR GAREHNLKNV DLDLPRDSLI VMTGLSGSGK SSLAFDTIYA EGQRRYVESL
SAYARQFLEM MQKPDVDQID GLSPAISIEQ KTTSKNPRST VGTVTEIYDY MRLLFARVGV
PYSPATGLPI ESQTVSQMVD RVLALEEGTR LFLLAPIVRG RKGEYRKELL ELQKKGFQRV
KVDGVFYEIA DVPALDKKYK HDIDVVVDRI VVRGDLATRL ADSIETALKL AEGLAVAEFA
DKPLDSSQTG EDSVNKSKNE THERILFSEK FACPVSGFTI PEIEPRLFSF NNPFGACPTC
DGLGSQRAID PNLVVPDENV SLRDGAVSPW AKSTSPYYVQ TLEALGKAYN FKLGDKFKDL
SAEAQDAILR GTGEREVTFQ YDDGLRSYKT TKTFEGVIPN LERRWKETES AWMREEIERF
MSATPCPVCK GYRLKPEALA VKIGGKHIGE VTEQSIRNAD KWFTDLPAQL NDKQNEIAVR
VLKEIRERLR FLNDVGLDYL TLSRNSGTLS GGESQRIRLA SQIGSGLTGV LYVLDEPSIG
LHQRDNTRLL DTLKHLRDIG NTVIVVEHDE DAILHADYVV DMGPAAGIHG GEIIAQGTPQ
QVMANPNSIT GKYLSGALEV ATPGVRREAK KNRRLKIVGA RGNNLKNVTA EIPLGTFTAV
TGVSGGGKST FLIETLFKAA SRRIMGSREH PAEHDRIEGL EFLDKVIDID QSPIGRTPRS
NPATYTGAFT PIRDWFAGLP EAKARGYQPG RFSFNVKGGR CEACQGDGVI KIEMHFLPDV
YVTCDVCHGK RYNRETLDVL FKGKSIADVL DMTVEEGVDF FAAVPGVRDK LDTLKQVGLG
YIHIGQQATT LSGGEAQRIK LAKELSRKAT GKTLYILDEP TTGLHFHDVA KLLEVLHELV
DQGNTVVVIE HNLEVIKTAD WVLDLGPEGG DGGGELVAQG TPEAIVREKR SYTGQFLKEL
LERRPGGKRE AAE
