ID   UVRA_RICBR              Reviewed;         953 AA.
AC   Q1RK71;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2006, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE            Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN   Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=RBE_0162;
OS   Rickettsia bellii (strain RML369-C).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; belli group.
OX   NCBI_TaxID=336407;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RML369-C;
RX   PubMed=16703114; DOI=10.1371/journal.pgen.0020076;
RA   Ogata H., La Scola B., Audic S., Renesto P., Blanc G., Robert C.,
RA   Fournier P.-E., Claverie J.-M., Raoult D.;
RT   "Genome sequence of Rickettsia bellii illuminates the role of amoebae in
RT   gene exchanges between intracellular pathogens.";
RL   PLoS Genet. 2:733-744(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC       A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC       scans DNA for abnormalities. When the presence of a lesion has been
CC       verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC       Rule:MF_00205}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR   EMBL; CP000087; ABE04243.1; -; Genomic_DNA.
DR   RefSeq; WP_011476857.1; NC_007940.1.
DR   AlphaFoldDB; Q1RK71; -.
DR   SMR; Q1RK71; -.
DR   STRING; 336407.RBE_0162; -.
DR   PRIDE; Q1RK71; -.
DR   EnsemblBacteria; ABE04243; ABE04243; RBE_0162.
DR   KEGG; rbe:RBE_0162; -.
DR   eggNOG; COG0178; Bacteria.
DR   HOGENOM; CLU_001370_0_2_5; -.
DR   OMA; PFEGIIP; -.
DR   OrthoDB; 152379at2; -.
DR   Proteomes; UP000001951; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.40.50.300; -; 3.
DR   HAMAP; MF_00205; UvrA; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   InterPro; IPR041102; UvrA_inter.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   Pfam; PF17760; UvrA_inter; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW   Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..953
FT                   /note="UvrABC system protein A"
FT                   /id="PRO_0000278041"
FT   DOMAIN          320..599
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   DOMAIN          619..949
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         752..778
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         33..40
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         652..659
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ   SEQUENCE   953 AA;  106285 MW;  8D7BF227C2EB5448 CRC64;
     MNQEYIKVRG AKEHNLKNIN VDIPRNKFVV ITGLSGSGKS SLAFDTIYAE GQRRYVESLS
     SYARQFLHLQ NKPNVESISG LSPAIAIDQK TTSKNPRSTV GTITEIYDYL RLLYARVGIP
     YSPATGLPIH SQTVSEMVDI INELPQGTKI YLLAPIVRGH KGEFKREIMN LKKQGFQKLI
     VNGETCEIDD LPKLDKNKKH NIEVIVDRIV LDENLGNRLA DSLESSLNLA DGITYLEIVE
     LPTAANTEYE KNQRITFSEK YSCPVSGFQL TEIEPRIFSF NSPFGACPKC EGIGKEFFFD
     RDLIVPDHRI SIKDGAIVPW GSTSSKFILE TLKALAEHYR FSIESPFSAL SDNIKTILFE
     GSGEEAIRFE FHDGSKTQVI HQPFAGIIPS LQEKDRTIES VLIKEELAKF KSEHKCTACN
     GYRLKDEALC VKIVNIHIGE VADMSIATLQ QWFAHLEQKL NKKQLFIAER ILKEINERLK
     FLMNVGLDYL TLSRESGTLS GGESQRIRLA SQIGSGLSGV LYVLDEPSIG LHQRDNTRLI
     ETLKRLRDLG NTVLVVEHDE ETMYEADHII DIGPGAGIHG GRVIAEGNAE EIKNFEESIT
     GRYLSGRQTI KVPTQTRTGH DNRAIELIGA VSNNLDNVDI KIPLGTFTAI TGVSGSGKSS
     LMIHTLYKAA LKHLEPTAKV FPGKYQKLKG LEYIDKIIDI NQSPIGRTPR SNPATYTGAF
     THIRDWFVEL PESKARGYKV GRFSFNVKGG RCEACQGDGL IKIEMHFLPD VYVKCDICNG
     HRYNRETLEI KYKGKSIADI LMMTVEDAMQ FFEKIPLIYE KLITLNEVGL GYIKIGQSAT
     TLSGGEAQRV KLAKELSRRS TGKTLYILDE PTTGLHIDDI NKLLKVLHKL VDMGNTVLVI
     EHNLDVIKTA DYIIDVGPEG GDKGGKIVVH GTPADIAACS ESHTGRYLKQ YLK