UVRA_RICTY
ID UVRA_RICTY Reviewed; 953 AA.
AC Q68Y12;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=RT0823;
OS Rickettsia typhi (strain ATCC VR-144 / Wilmington).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC Rickettsiaceae; Rickettsieae; Rickettsia; typhus group.
OX NCBI_TaxID=257363;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC VR-144 / Wilmington;
RX PubMed=15317790; DOI=10.1128/jb.186.17.5842-5855.2004;
RA McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E.,
RA McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E.,
RA Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A., Hong C.,
RA Yu X.-J., Walker D.H., Weinstock G.M.;
RT "Complete genome sequence of Rickettsia typhi and comparison with sequences
RT of other Rickettsiae.";
RL J. Bacteriol. 186:5842-5855(2004).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE017197; AAU04278.1; -; Genomic_DNA.
DR RefSeq; WP_011191252.1; NC_006142.1.
DR AlphaFoldDB; Q68Y12; -.
DR SMR; Q68Y12; -.
DR STRING; 257363.RT0823; -.
DR EnsemblBacteria; AAU04278; AAU04278; RT0823.
DR KEGG; rty:RT0823; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_5; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000000604; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..953
FT /note="UvrABC system protein A"
FT /id="PRO_0000278043"
FT DOMAIN 320..599
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 619..949
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 752..778
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 652..659
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 953 AA; 106233 MW; 5E86D2FC08DA5A43 CRC64;
MNEEYIKVRG AKEHNLKNIN VDIPRNKFVV ITGLSGSGKS SLAFDTIYAE GQRRYVESLS
SYARQFLHLQ NKPNVESISG LSPAIAIDQK TTSKNPRSTV GTITEIYDYL RLLYARVGIP
YSPVTGLPIH SQTVAEMVDI INELPKGTKV YLLAPIVRGH KGEFRREIIN LKKQGFQKLI
VNGEVCEIDD LPKLDKNKKH NIEVIVDRIV LDENLGNRLA DSLESSLNLA DGITYLEIVE
LPQAVKSQFK KNQRITFSEK YSCPVSGFHL TEIEPRIFSF NSPFGACPKC EGIGKEFFFD
RDLIVQDQRI SIKDGAIVPW GSTSSKFILE TLKALADHYK FSIEVPFISL SQNVKDILFE
GSGEEEIKFE FHDGSKTQII KQPFAGIIPS LQEKDRTIES VLIKEELAKF KSEHKCTACS
GFRLKDEALC VKIANLHIGE VAGMSIAALQ KWFSHLEEKL NQKQLFIAKR ILKEINERLK
FLMNVGLDYL TLSREAGTLS GGESQRIRLA SQIGSGLSGV LYVLDEPSIG LHQRDNTRLI
ATLKRLRDLG NTVLVVEHDE ETMYEADHII DIGPGAGIHG GRVIAEGNAE KIKHFEESIT
GRYLSGRQTI KVPSETRVGH DNRAIELLGA VSNNLDNVDI KIPLGTFTAI TGVSGSGKSS
LMIHTLYKAA LKHLEPTSKV FPGKYRELKG LEYIDKIIDI NQSPIGRTPR SNPATYTGAF
THIRDWFVEL PESKARGYKV GRFSFNVKGG RCEACQGDGL IKIEMHFLPD VYVKCDICNG
HRYNRETLEI KYKGKSIADI LMMTVEDAMQ FFDKIPLIYE KLITLNEVGL GYIKIGQSAT
TLSGGEAQRV KLAKELSRRS TGKTLYILDE PTTGLHIDDI KKLLKVLHKL VDMGNTVLVI
EHNLDVIKTA DYIIDVGPEG GDKGGKIVVC GTPADIAACK ESHTGRYLKQ YLV
