UVRA_STAES
ID UVRA_STAES Reviewed; 944 AA.
AC Q8CPY9;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=SE_0542;
OS Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176280;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 12228 / FDA PCI 1200;
RX PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT "Genome-based analysis of virulence genes in a non-biofilm-forming
RT Staphylococcus epidermidis strain (ATCC 12228).";
RL Mol. Microbiol. 49:1577-1593(2003).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE015929; AAO04139.1; -; Genomic_DNA.
DR RefSeq; NP_764097.1; NC_004461.1.
DR RefSeq; WP_002485563.1; NZ_WBME01000015.1.
DR AlphaFoldDB; Q8CPY9; -.
DR SMR; Q8CPY9; -.
DR STRING; 176280.SE_0542; -.
DR EnsemblBacteria; AAO04139; AAO04139; SE_0542.
DR KEGG; sep:SE_0542; -.
DR PATRIC; fig|176280.10.peg.513; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_9; -.
DR OMA; PFEGIIP; -.
DR Proteomes; UP000001411; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..944
FT /note="UvrABC system protein A"
FT /id="PRO_0000093095"
FT DOMAIN 309..587
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 607..935
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 252..279
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 738..764
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 33..40
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 639..646
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 944 AA; 105158 MW; BEF11DDAF5B05C0F CRC64;
MKGPSIVVKG ARAHNLKGVD IELPKNKLIV MTGLSGSGKS SLAFDTIYAE GQRRYVESLS
AYARQFLGQM DKPDVDTIEG LSPAISIDQK TTSKNPRSTV ATVTEIYDYI RLLYARVGKP
YCPYHGIEIE SQTVQQMVDR ILELEERTKI QLLAPVISHR KGSHEKLIED IGKKGYVRLR
VDDEIVDVNE VPQLDKNKNH TIEVVVDRLV VKDGIETRLA DSIETALELA EGNLTVDVIN
GEELKFSENH ACPICGFSIG ELEPRMFSFN SPFGACPTCD GLGQKLKVDL DLVIPDKNKT
LNEGAIEPWE PTSSDFYPTL LKRVCEVYKI NMDKPYKKLT DRQKNILMNG SGEKEIEFTF
TQRNGGTRKR KMVFEGVVPN IDRRYHESPS EYTREMMSKY MTELPCETCH GKRLSKEALS
VYVGDYNIGE VVEYSIKNAL YYFENLKLSD QDKSIADQIL KEIISRLSFL NNVGLEYLTL
DRSSGTLSGG EAQRIRLATQ IGSRLTGVLY VLDEPSIGLH QRDNDRLINT LKEMRDLGNT
LIVVEHDDDT MRAADYLVDV GPGAGNHGGE VVSSGTPNKV MKDKKSLTGQ YLSGKKRIEV
PEYRREITDR KIQIKGAKSN NLKNVNVDFP LSVLTVVTGV SGSGKSSLVN EILYKALAQK
INKSKVKPGN FDEIKGIDQL DKIIDIDQSP IGRTPRSNPA TYTGVFDDIR DVFAQTNEAK
IRGYQKGRFS FNVKGGRCEA CKGDGIIKIE MHFLPDVYVP CEVCDGKRYN RETLEVTYKG
KNIADVLEMT VEEATHFFEN IPKIKRKLQT LVDVGLGYIT LGQQGTTLSG GEAQRVKLAS
ELHKRSTGRS IYILDEPTTG LHVDDISRLL KVLNRIVENG DTVVIIEHNL DVIKTADHII
DLGPEGGEGG GTIIATGTPE EIAQNKGSYT GQYLKPVLER DSVE
