ID   CAEA_CONTS              Reviewed;          20 AA.
AC   P86362;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Alpha-conotoxin-like ts14a {ECO:0000303|PubMed:20691232};
OS   Conus tessulatus (Tessellate cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Tesselliconus.
OX   NCBI_TaxID=101317;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, AND DISULFIDE
RP   BONDS.
RC   TISSUE=Venom;
RX   PubMed=20691232; DOI=10.1016/j.peptides.2010.07.011;
RA   Peng C., Ye M., Wang Y., Shao X., Yuan D., Liu J., Hawrot E., Wang C.,
RA   Chi C.;
RT   "A new subfamily of conotoxins belonging to the A-superfamily.";
RL   Peptides 31:2009-2016(2010).
CC   -!- FUNCTION: Alpha-conotoxins act on postsynaptic membranes, they bind to
CC       the nicotinic acetylcholine receptors (nAChR) and thus inhibit them.
CC       {ECO:0000250|UniProtKB:C6ZJQ2}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20691232}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:20691232}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2091.76; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20691232};
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000255}.
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DR   AlphaFoldDB; P86362; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0035792; C:host cell postsynaptic membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; ISS:UniProtKB.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Acetylcholine receptor inhibiting toxin; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Postsynaptic neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..20
FT                   /note="Alpha-conotoxin-like ts14a"
FT                   /evidence="ECO:0000269|PubMed:20691232"
FT                   /id="PRO_0000405802"
FT   DISULFID        3..16
FT                   /evidence="ECO:0000269|PubMed:20691232"
FT   DISULFID        14..20
FT                   /evidence="ECO:0000269|PubMed:20691232"
SQ   SEQUENCE   20 AA;  2097 MW;  458908B21DBDD58A CRC64;
     DGCPPHPVPG MHPCMCTNTC