UVRA_TREPA
ID UVRA_TREPA Reviewed; 960 AA.
AC O83527;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=TP_0514;
OS Treponema pallidum (strain Nichols).
OC Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX NCBI_TaxID=243276;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nichols;
RX PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA Venter J.C.;
RT "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL Science 281:375-388(1998).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE000520; AAC65502.1; -; Genomic_DNA.
DR PIR; A71315; A71315.
DR RefSeq; WP_010881963.1; NC_021490.2.
DR AlphaFoldDB; O83527; -.
DR SMR; O83527; -.
DR IntAct; O83527; 7.
DR STRING; 243276.TPANIC_0514; -.
DR EnsemblBacteria; AAC65502; AAC65502; TP_0514.
DR GeneID; 57879037; -.
DR KEGG; tpa:TP_0514; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_12; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000000811; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..960
FT /note="UvrABC system protein A"
FT /id="PRO_0000093109"
FT DOMAIN 327..605
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 625..953
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 270..297
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 756..782
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 35..42
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 657..664
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 960 AA; 106010 MW; 32F78624B19F7ABF CRC64;
MGSAARNLCI KGAREHNLKN IDVMLPRDAL VVISGLSGSG KSSLAFDTIF AEGQRRYVES
LSAYARQFLG RLDKPDVDSI EGLSPAIAIE QKTTQRNPRS TVGTVTEIYD YYRLLFARIG
RAHCPHCARE IKEQTVDQIV DTLMTVPSGS RIQLLAPVVR GKKGTHHKVL EAARKDGFVR
ARIDGALLHL HERISLDKQK KHSIDIVVDR IQLSDTVRKR LTESVETTLG YADGLLTVLV
QGENSGTVSG KIETSALLPS ELFFSQKNAC AHCNVSVPEL QPRLFSFNAP FGACPSCAGL
GIMQTFDLDR IVPDQNRSFN EGAFLPFKPE HEWNRVRFAA LAEKYHFSLD DPVRNLSKHA
LDIILHGSGS EALEFSHERK DGSRTARYIK PWPGIFSELH RRYAESCTHS QREVYERYLS
VRTCEACRGM RLKPESLAVT IEKKNIHALS ALSVDDSCEF FKTLHLTEVE ATIAQQILKE
ITDRLEFLQN VGLGYLTLER AAATLSGGEA QRIRLATQIG SRLTGVLYIL DEPSIGLHQR
DNERLIQTLL HLRDLGNTVL VVEHDEQTLR VADYIVDLGP GAGVHGGYVV AAGSPPEVMQ
VQASLTGQYL AGAITLPIPA VRRTGNGNVL TVHDVHEHNL QHISVRIRLG TFTCITGVSG
SGKSTLLIDV LYPALYNRVM NGRLPEGKFS SIEGTEHLDK VIYVDQSPIG RTPRSNPATY
VGVFTDIRML FSQVPEAKMR GYKPGRFSFN VPGGRCEHCK GDGVITIEMN FLPDVYITCD
VCHGTRFNRE TLAVFYKGKN ISHVLDMTIE EARSFFSAVP PIVRKLEALC SVGLGYVRLG
QSALTLSGGE AQRVKLALEL SKRATGKTLY IFDEPTTGLH FADIIQLMEV VQRLVDQGNT
VVMIEHNMDV IVQADCVIDL GPEGGMHGGT IVAQGSPEAV SQITESRTGW YIKEVLCKKT
