ID   UVRA_UREPA              Reviewed;         943 AA.
AC   Q9PR42;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE            Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN   Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=UU102;
OS   Ureaplasma parvum serovar 3 (strain ATCC 700970).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Ureaplasma.
OX   NCBI_TaxID=273119;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700970;
RX   PubMed=11048724; DOI=10.1038/35037619;
RA   Glass J.I., Lefkowitz E.J., Glass J.S., Heiner C.R., Chen E.Y.,
RA   Cassell G.H.;
RT   "The complete sequence of the mucosal pathogen Ureaplasma urealyticum.";
RL   Nature 407:757-762(2000).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC       A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC       scans DNA for abnormalities. When the presence of a lesion has been
CC       verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC       Rule:MF_00205}.
CC   -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC       lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR   EMBL; AF222894; AAF30508.1; -; Genomic_DNA.
DR   RefSeq; WP_006688528.1; NC_002162.1.
DR   AlphaFoldDB; Q9PR42; -.
DR   SMR; Q9PR42; -.
DR   STRING; 273119.UU102; -.
DR   PRIDE; Q9PR42; -.
DR   EnsemblBacteria; AAF30508; AAF30508; UU102.
DR   GeneID; 29672710; -.
DR   KEGG; uur:UU102; -.
DR   eggNOG; COG0178; Bacteria.
DR   HOGENOM; CLU_001370_0_2_14; -.
DR   OMA; PFEGIIP; -.
DR   Proteomes; UP000000423; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1490.20; -; 1.
DR   Gene3D; 3.40.50.300; -; 2.
DR   HAMAP; MF_00205; UvrA; 1.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR004602; UvrA.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   InterPro; IPR041102; UvrA_inter.
DR   Pfam; PF00005; ABC_tran; 1.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   Pfam; PF17760; UvrA_inter; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   TIGRFAMs; TIGR00630; uvra; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW   Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW   Repeat; SOS response; Zinc; Zinc-finger.
FT   CHAIN           1..943
FT                   /note="UvrABC system protein A"
FT                   /id="PRO_0000093110"
FT   DOMAIN          309..588
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   DOMAIN          608..937
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         252..279
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   ZN_FING         739..765
FT                   /note="C4-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         31..38
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT   BINDING         640..647
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ   SEQUENCE   943 AA;  105226 MW;  247C65AF094420A4 CRC64;
     MDKIIIKGAR ENNLKNIDLE IPKNKLVVIT GVSGSGKSSL AFDTIFAEGK RRYFESLSSY
     ARQFLGGNDK ADVESIEGLS PTIAVDQKST NQNPRSIVGT ITEIYDYLRV LFARVGTPFC
     PNGHGQIKSQ TPKQIADFLF SLSPKSKIQI LAPIEIKKGY KINDVLNNLR NQGYLRVLVN
     NEVYQLDENL PQFLDNKKTD VAIIVDRLIL NIDHQTKTRA LDAIEFALNY SGGEIAFKVN
     DDIHYFTQND VCQVCGFKIK EIEPTLFSFN SPIGACEQCK GLGYNYVPDE RKMIPNPNLS
     INEGGLDYFK NTVNTTNLDW QRFNSIIKHY KIDKTKPLKE LDRKEIDLLL YGSDEAIEID
     ITSANNKKYS SIDYVEGVLE LVNRRYQETS SELAREHYNK YMSEKVCKSC KGKKLSSQAL
     SVLINKINII DFIEKNIDEA IDFLLHLDLN EAQTKIANPI LKEVLDRLGF LKNVGLEYLT
     LARPASSLSG GEAQRIRLAT QIGSKLTGIL YVLDEPSIGL HQRDNDKLIN TLKEMRDLGN
     TVIVVEHDEE TMLAADYLID IGPQAGVNGG YVIAAGTPQE VMQNPNSLTG QYLSKQKDIL
     VPKTRRSGNG HKVILKGAKH NNLKNVDLTI PLGKFICVTG VSGSGKSSLI LETLVKAIEY
     TNFNPFVIPG EYKDLIGASN VDKIVVVNQD AIGRTTRSNP ATYVGVFDDI RTVFENTIEA
     KARGYSKSRF SFNIKGGRCE RCWGDGTIRI EMHFLPDVYI SCEECHGKRY NDETLQVKFK
     GKSIYDVLKM PIDEALVFFE NYPGIHRKLQ LLVDVGLGYL ELGASSTSLS GGEAQRIKLA
     KFLQRKPTGK TLFVLDEPTT GLHIDDVAKL IKILDKIVDG GDTVLVIEHN LDLIKVADYI
     IDIGPEGGNK GGKIIATGTP EQLLSKKDIS YTAQYLEKYL KKN