UVRA_VIBCH
ID UVRA_VIBCH Reviewed; 940 AA.
AC Q9KUW5;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=VC_0394;
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AE003852; AAF93567.1; -; Genomic_DNA.
DR PIR; A82329; A82329.
DR RefSeq; NP_230048.1; NC_002505.1.
DR RefSeq; WP_000357696.1; NZ_LT906614.1.
DR AlphaFoldDB; Q9KUW5; -.
DR SMR; Q9KUW5; -.
DR STRING; 243277.VC_0394; -.
DR PRIDE; Q9KUW5; -.
DR DNASU; 2614991; -.
DR EnsemblBacteria; AAF93567; AAF93567; VC_0394.
DR GeneID; 57739133; -.
DR KEGG; vch:VC_0394; -.
DR PATRIC; fig|243277.26.peg.369; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_6; -.
DR OMA; PFEGIIP; -.
DR BioCyc; VCHO:VC0394-MON; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..940
FT /note="UvrABC system protein A"
FT /id="PRO_0000093111"
FT DOMAIN 309..586
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 606..936
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 252..279
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 739..765
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 31..38
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 639..646
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 940 AA; 104328 MW; 84F93B9DF686F6F2 CRC64;
MDKIEVRGAR THNLKNINLT IPRDKLIVIT GLSGSGKSSL AFDTLYAEGQ RRYVESLSAY
ARQFLSLMEK PDVDHIEGLS PAISIEQKST SHNPRSTVGT ITEVYDYLRL LYARVGEPRC
PEHQVPLKAQ TISQMVDKVL ELPEGSKMML LATIVKERKG EHVKTLENLA AQGFIRARID
GETCDLTDPP KLELHKKHTI EVIVDRFKVR SDLQQRLAES FETALELSGG IVVVAPMEGD
GEEQIFSANF ACPHCGYSMR ELEPRLFSFN NPAGACPTCD GLGVQQYFDP DRVIQDANLS
LAQGAIRGWD QKNFYYFQML TALAEHYDFD VHTPFNKLSK KIQEIILHGS GRTEIEFKYI
NDRGDIRLKK HPFEGILHNL ERRYRDTESN SVREELAKYI SNKPCSSCDG TRLKIEARNV
FINDTALPTI VELSIADALT FFQELKLEGQ RAQIAEKVMK EINDRLQFLV NVGLNYLNLS
RSAETLSGGE AQRIRLASQI GAGLVGVMYV LDEPSIGLHQ RDNERLLQTL THLRNLGNTV
LVVEHDEDAI RMADHVIDIG PGAGVHGGMV VAEGNVEEII ANPNSLTGQY LSGVKKIAVP
EQRTPKDAKK TVELKGAVGN NLKNVDLSIP VGLFTCVTGV SGSGKSTLIN DTFFKIAHTA
LNGATTATPA PYRSIQGLEH FDKVIDIDQS PIGRTPRSNP ATYTGIFTPI RELFAGTQES
RSRGYQPGRF SFNVRGGRCE ACQGDGVIKV EMHFLPDVYV PCDVCKGKRY NRETLEVRYK
GKTIDEVLDM TVEDAREFFD PVPVIARKLQ TLMDVGLSYI RLGQSATTLS GGEAQRVKLA
RELSKRDTGK TLYILDEPTT GLHFHDIQQL LSVLHRLRDH GNTVVVIEHN LDVIKTADWI
IDLGPEGGQG GGLIIAEGTP EDVAQIEASH TARFLKPLLN
