UVRA_ZYMMO
ID UVRA_ZYMMO Reviewed; 946 AA.
AC O31151; Q5NM48;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 2.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=ZMO1588;
OS Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC Zymomonadaceae; Zymomonas.
OX NCBI_TaxID=264203;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 31821 / ZM4 / CP4;
RA Kang H.L., Jin S.J., Kang H.S.;
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31821 / ZM4 / CP4;
RX PubMed=15592456; DOI=10.1038/nbt1045;
RA Seo J.-S., Chong H., Park H.S., Yoon K.-O., Jung C., Kim J.J., Hong J.H.,
RA Kim H., Kim J.-H., Kil J.-I., Park C.J., Oh H.-M., Lee J.-S., Jin S.-J.,
RA Um H.-W., Lee H.-J., Oh S.-J., Kim J.Y., Kang H.L., Lee S.Y., Lee K.J.,
RA Kang H.S.;
RT "The genome sequence of the ethanologenic bacterium Zymomonas mobilis
RT ZM4.";
RL Nat. Biotechnol. 23:63-68(2005).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AF086791; AAC70369.1; -; Genomic_DNA.
DR EMBL; AE008692; AAV90212.1; -; Genomic_DNA.
DR PIR; T33732; T33732.
DR RefSeq; WP_011241346.1; NZ_CP035711.1.
DR AlphaFoldDB; O31151; -.
DR SMR; O31151; -.
DR STRING; 264203.ZMO1588; -.
DR PRIDE; O31151; -.
DR EnsemblBacteria; AAV90212; AAV90212; ZMO1588.
DR GeneID; 58027310; -.
DR KEGG; zmo:ZMO1588; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_5; -.
DR OMA; PFEGIIP; -.
DR OrthoDB; 152379at2; -.
DR Proteomes; UP000001173; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1490.20; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR TIGRFAMs; TIGR00630; uvra; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Reference proteome;
KW Repeat; SOS response; Zinc; Zinc-finger.
FT CHAIN 1..946
FT /note="UvrABC system protein A"
FT /id="PRO_0000093121"
FT DOMAIN 311..592
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 612..940
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 743..769
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 32..39
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 644..651
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT CONFLICT 87
FT /note="E -> G (in Ref. 1; AAC70369)"
FT /evidence="ECO:0000305"
FT CONFLICT 514..535
FT /note="LYVLDEPSIGLHQRDNDRLLET -> YMCWMNPLSVCISVIMIACLKP (in
FT Ref. 1; AAC70369)"
FT /evidence="ECO:0000305"
FT CONFLICT 916..946
FT /note="GQIIAAGTPEKVAETEGSYTGHYLKRMLQPK -> WPLFKTDAST (in
FT Ref. 1; AAC70369)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 946 AA; 104011 MW; 8961197F92AFD707 CRC64;
MLSTISIRGA REHNLKNVSI DIPRNKLVVM TGLSGSGKSS LAFDTIYAEG QRRYVESLSA
YARQFLEMMQ KPDVDHIEGL SPAISIEQKT TSKNPRSTVA TVTEIYDYMR LLWARVGIPY
SPATGLPITA QTVSQMVDRV MALPEGSRLH LLAPVVRGRK GEYRKEMAEW QKAGFSRLRI
DGEYYLIEEA PKIDKKRKHD IEVVVDRLVI KEGLETRLAQ SLETALKLAG GIAISEPADE
GSFEPMLFSE HFSCPVSGFT IPEIEPRLFS FNAPQGACPA CDGLGEKPYF DVRLIVPNES
LSLAKGALMP WARSTPPSPY YMQILSSLAR YYDFSLETPW KKLPEKIQNV ILYGSEGEVI
PLRFSEGNQI YEVEKAFEGV IRNLERRLVT TDSESIREDI GRYQSAAPCE VCHGARLRPE
ALAVLIDHHN ISDVTKMTVK PALEFFRQLP EKLTEAQNQI AERILKEIIE RLGFLDNVGL
DYLSLDRSSG TLSGGESQRI RLASQIGSGL SGVLYVLDEP SIGLHQRDND RLLETLKRLR
DLGNSVLVVE HDEDAIRLAD YVVDMGPGAG VMGGKVIAAG SPQDIIDCPD SLTGAYLSGR
REIAVPDKRR KGNGKKLTIK GATANNLQNV TASIPLGTFT CVTGVSGSGK SSLILDTLYT
AAARELNGAR LISGDYKSIS GLEHLDKVID IDQSPIGRTP RSNPATYTGA FTAIREWFAK
LPEAQARGYK AGRFSFNVKG GRCEACQGDG VKKIEMHFLP DVYVTCDVCH GARYNRETQE
VKFKGQSIAD VLNMTVDQAA EFFEAVPSIR DKMAMLARVG LGYIKVGQQA TTLSGGEAQR
VKLAKELSKR ATGRTLYILD EPTTGLHFED VRKLLEVLNA LVDQGNSIVV IEHNLDVIKT
ADWLIDLGPE GGTGGGQIIA AGTPEKVAET EGSYTGHYLK RMLQPK
