ID   CAEG_CONBE              Reviewed;          40 AA.
AC   A0A068B409;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2014, sequence version 1.
DT   03-AUG-2022, entry version 22.
DE   RecName: Full=Conotoxin Bt14.16 {ECO:0000312|EMBL:AIC77093.1};
DE   Flags: Precursor; Fragment;
OS   Conus betulinus (Beech cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dendroconus.
OX   NCBI_TaxID=89764;
RN   [1] {ECO:0000312|EMBL:AIC77093.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Venom gland;
RA   Zhang L.X., Liu Z.G., Dai Q.Y.;
RL   Submitted (JUL-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|PDB:7EDK}
RP   STRUCTURE BY NMR OF 19-37, AND DISULFIDE BONDS.
RA   Zhang H., Lin D., Guo C.;
RT   "Structure of peptide Bt14.12.";
RL   Submitted (MAR-2021) to the PDB data bank.
CC   -!- FUNCTION: Probable neurotoxin with unknown target. Possibly targets ion
CC       channels. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305}.
CC   -!- DOMAIN: The cysteine framework is XIV (C-C-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin A superfamily. {ECO:0000305}.
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DR   EMBL; KF414110; AIC77093.1; -; Genomic_DNA.
DR   PDB; 7EDK; NMR; -; A=19-37.
DR   PDBsum; 7EDK; -.
DR   SMR; A0A068B409; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:InterPro.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR009958; Conotoxin_a-typ.
DR   Pfam; PF07365; Toxin_8; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Toxin.
FT   PROPEP          <1..18
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000455522"
FT   PEPTIDE         19..40
FT                   /note="Conotoxin Bt14.16"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000455523"
FT   DISULFID        21..36
FT                   /evidence="ECO:0007744|PDB:7EDK"
FT   DISULFID        24..29
FT                   /evidence="ECO:0007744|PDB:7EDK"
FT   NON_TER         1
FT                   /evidence="ECO:0000305|Ref.1"
SQ   SEQUENCE   40 AA;  4495 MW;  DDA2B2916AB832F7 CRC64;
     SDGRDAAVIY TESDVIARGD CKPCMHPDCR FNPGRCRPRE