ID   CAER2_XENLA             Reviewed;         136 AA.
AC   P05223;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Preprocaerulein type I';
DE   Flags: Precursor; Fragment;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Skin;
RX   PubMed=3753978; DOI=10.1016/s0021-9258(17)35700-9;
RA   Richter K., Egger R., Kreil G.;
RT   "Sequence of preprocaerulein cDNAs cloned from skin of Xenopus laevis. A
RT   small family of precursors containing one, three, or four copies of the
RT   final product.";
RL   J. Biol. Chem. 261:3676-3680(1986).
CC   -!- FUNCTION: The pharmacological activities of caerulein are quite similar
CC       to the physiological activities of gastrin and related peptides.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   EMBL; M12493; AAA49683.1; -; mRNA.
DR   PIR; B23364; B23364.
DR   AlphaFoldDB; P05223; -.
DR   TCDB; 1.C.16.1.2; the magainin (magainin) family.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Amphibian defense peptide; Cleavage on pair of basic residues;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   PROPEP          27..>136
FT                   /id="PRO_0000010496"
FT   REGION          82..101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..101
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         136
SQ   SEQUENCE   136 AA;  14460 MW;  3A733CC208D43FD3 CRC64;
     MFKGILLCVL FAVLSANPLS QPEGFADEER DVRGLASFLG KALKAGLKND DDVNERDVRG
     FASFLGKALK AALKIGANAL GGAPQQREAN DERRFADDED DVNERDVRGF GSFLGKALKA
     ALKIGANALG GAPQQR