CAER_LITPE
ID CAER_LITPE Reviewed; 10 AA.
AC P86486;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 1.
DT 11-DEC-2019, entry version 6.
DE RecName: Full=Caerulein {ECO:0000303|PubMed:19642086};
OS Litoria peronii (Emerald spotted tree frog) (Hyla peronii).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Litoria.
OX NCBI_TaxID=317363;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY,
RP DEVELOPMENTAL STAGE, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT GLN-1,
RP SULFATION AT TYR-4, AND AMIDATION AT PHE-10.
RC TISSUE=Skin secretion {ECO:0000269|PubMed:19642086};
RX PubMed=19642086; DOI=10.1002/rcm.4164;
RA Bilusich D., Jackway R.J., Musgrave I.F., Tyler M.J., Bowie J.H.;
RT "The host-defence skin peptide profiles of Peron's Tree Frog Litoria
RT peronii in winter and summer. Sequence determination by electrospray mass
RT spectrometry and activities of the peptides.";
RL Rapid Commun. Mass Spectrom. 23:2628-2636(2009).
CC -!- FUNCTION: Induces contraction of intestinal smooth muscle in isolated
CC guinea pig ileum. {ECO:0000269|PubMed:19642086}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19642086}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC {ECO:0000269|PubMed:19642086}.
CC -!- DEVELOPMENTAL STAGE: Expressed during summer and winter.
CC {ECO:0000269|PubMed:19642086}.
CC -!- MASS SPECTROMETRY: Mass=1351; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:19642086};
CC -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC {ECO:0000255}.
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DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0045987; P:positive regulation of smooth muscle contraction; IDA:UniProtKB.
DR InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR PROSITE; PS00259; GASTRIN; 1.
PE 1: Evidence at protein level;
KW Amidation; Amphibian defense peptide; Direct protein sequencing;
KW Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT PEPTIDE 1..10
FT /note="Caerulein"
FT /evidence="ECO:0000269|PubMed:19642086"
FT /id="PRO_0000394176"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:19642086"
FT MOD_RES 4
FT /note="Sulfotyrosine"
FT /evidence="ECO:0000269|PubMed:19642086"
FT MOD_RES 10
FT /note="Phenylalanine amide"
FT /evidence="ECO:0000269|PubMed:19642086"
SQ SEQUENCE 10 AA; 1290 MW; 99DBF3837861BB5A CRC64;
QQDYTGWMDF