ID   CAER_PHAJA              Reviewed;           9 AA.
AC   P86625;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   11-DEC-2019, entry version 6.
DE   RecName: Full=[Arg4]-Phyllocaerulein {ECO:0000303|PubMed:20932854};
OS   Phasmahyla jandaia (Jandaia leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phasmahyla.
OX   NCBI_TaxID=762504;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AMIDATION AT PHE-9, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:20932854};
RX   PubMed=20932854; DOI=10.1016/j.toxicon.2010.09.010;
RA   Rates B., Silva L.P., Ireno I.C., Leite F.S., Borges M.H., Bloch C. Jr.,
RA   De Lima M.E., Pimenta A.M.;
RT   "Peptidomic dissection of the skin secretion of Phasmahyla jandaia
RT   (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).";
RL   Toxicon 57:35-52(2011).
CC   -!- FUNCTION: Hypotensive neuropeptide. {ECO:0000250|UniProtKB:Q7LZC4}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20932854}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:20932854}.
CC   -!- MASS SPECTROMETRY: Mass=1212.4; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20932854};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Hypotensive agent; Pyrrolidone carboxylic acid; Secreted.
FT   PEPTIDE         1..9
FT                   /note="[Arg4]-Phyllocaerulein"
FT                   /evidence="ECO:0000269|PubMed:20932854"
FT                   /id="PRO_0000404636"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:20932854"
FT   MOD_RES         9
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:20932854"
SQ   SEQUENCE   9 AA;  1231 MW;  6C9FA68378641B5B CRC64;
     QEYRGWMDF