ID   CAER_RANXA              Reviewed;          10 AA.
AC   P56264;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   17-JUN-2020, entry version 55.
DE   RecName: Full=Caerulein;
OS   Ranoidea xanthomera (Northern orange-eyed tree frog) (Litoria xanthomera).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Litoria.
OX   NCBI_TaxID=79697;
RN   [1]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, SULFATION AT TYR-4,
RP   AMIDATION AT PHE-10, AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion;
RX   PubMed=9230483;
RX   DOI=10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k;
RA   Steinborner S.T., Waugh R.J., Bowie J.H., Wallace J.C., Tyler M.J.,
RA   Ramsay S.L.;
RT   "New caerin antibacterial peptides from the skin glands of the Australian
RT   tree frog Litoria xanthomera.";
RL   J. Pept. Sci. 3:181-185(1997).
CC   -!- FUNCTION: Hypotensive neuropeptide.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC   -!- MASS SPECTROMETRY: Mass=1354; Method=FAB;
CC       Evidence={ECO:0000269|PubMed:9230483};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
DR   PROSITE; PS00259; GASTRIN; 1.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Hypotensive agent; Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT   PEPTIDE         1..10
FT                   /note="Caerulein"
FT                   /id="PRO_0000043886"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:9230483"
FT   MOD_RES         4
FT                   /note="Sulfotyrosine"
FT                   /evidence="ECO:0000269|PubMed:9230483"
FT   MOD_RES         10
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:9230483"
SQ   SEQUENCE   10 AA;  1290 MW;  99DBF3837861BB5A CRC64;
     QQDYTGWMDF