ID   CAE_XENRU               Reviewed;          10 AA.
AC   C0HKM4;
DT   05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 1.
DT   11-DEC-2019, entry version 3.
DE   RecName: Full=Caerulein {ECO:0000303|PubMed:27290612};
OS   Xenopus ruwenzoriensis (Uganda clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=105430 {ECO:0000303|PubMed:27290612};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, PYROGLUTAMATE
RP   FORMATION AT GLN-1, SULFATION AT TYR-4, AND AMIDATION AT PHE-10.
RC   TISSUE=Skin secretion {ECO:0000303|PubMed:27290612};
RX   PubMed=27290612; DOI=10.1016/j.cbd.2016.04.006;
RA   Coquet L., Kolodziejek J., Jouenne T., Nowotny N., King J.D., Conlon J.M.;
RT   "Peptidomic analysis of the extensive array of host-defense peptides in
RT   skin secretions of the dodecaploid frog Xenopus ruwenzoriensis (Pipidae).";
RL   Comp. Biochem. Physiol. 19:18-24(2016).
CC   -!- FUNCTION: Induces contraction of intestinal smooth muscle in isolated
CC       guinea pig ileum. {ECO:0000250|UniProtKB:P86486}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27290612}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:27290612}.
CC   -!- MASS SPECTROMETRY: Mass=1272.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27290612};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   InterPro; IPR013152; Gastrin/cholecystokinin_CS.
PE   1: Evidence at protein level;
KW   Amidation; Amphibian defense peptide; Direct protein sequencing;
KW   Pyrrolidone carboxylic acid; Secreted; Sulfation.
FT   PEPTIDE         1..10
FT                   /note="Caerulein"
FT                   /evidence="ECO:0000269|PubMed:27290612"
FT                   /id="PRO_0000440919"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:27290612"
FT   MOD_RES         4
FT                   /note="Sulfotyrosine; partial"
FT                   /evidence="ECO:0000269|PubMed:27290612"
FT   MOD_RES         10
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:27290612"
SQ   SEQUENCE   10 AA;  1290 MW;  99DBF3837861BB5A CRC64;
     QQDYTGWMDF