ID   CAF17_DANRE             Reviewed;         354 AA.
AC   B8JMH0;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Putative transferase CAF17 homolog, mitochondrial;
DE            EC=2.1.-.-;
DE   AltName: Full=Iron-sulfur cluster assembly factor homolog;
DE   Flags: Precursor;
GN   Name=iba57; ORFNames=ch1073-162b20.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19656490; DOI=10.1016/j.cmet.2009.06.012;
RA   Nilsson R., Schultz I.J., Pierce E.L., Soltis K.A., Naranuntarat A.,
RA   Ward D.M., Baughman J.M., Paradkar P.N., Kingsley P.D., Culotta V.C.,
RA   Kaplan J., Palis J., Paw B.H., Mootha V.K.;
RT   "Discovery of genes essential for heme biosynthesis through large-scale
RT   gene expression analysis.";
RL   Cell Metab. 10:119-130(2009).
CC   -!- FUNCTION: Required for normal heme biosynthesis.
CC       {ECO:0000269|PubMed:19656490}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Morpholino knockdown of the protein results in
CC       profound anemia without affecting erythroid specification.
CC       {ECO:0000269|PubMed:19656490}.
CC   -!- SIMILARITY: Belongs to the GcvT family. {ECO:0000305}.
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DR   EMBL; CU633991; CAX13033.1; -; Genomic_DNA.
DR   RefSeq; NP_001070103.2; NM_001076635.2.
DR   AlphaFoldDB; B8JMH0; -.
DR   SMR; B8JMH0; -.
DR   STRING; 7955.ENSDARP00000055617; -.
DR   PaxDb; B8JMH0; -.
DR   PeptideAtlas; B8JMH0; -.
DR   Ensembl; ENSDART00000055618; ENSDARP00000055617; ENSDARG00000063446.
DR   GeneID; 100330979; -.
DR   KEGG; dre:100330979; -.
DR   CTD; 200205; -.
DR   ZFIN; ZDB-GENE-060929-712; iba57.
DR   eggNOG; KOG2929; Eukaryota.
DR   GeneTree; ENSGT00390000006465; -.
DR   HOGENOM; CLU_007884_7_1_1; -.
DR   InParanoid; B8JMH0; -.
DR   OMA; MDRLHGV; -.
DR   OrthoDB; 1342242at2759; -.
DR   PhylomeDB; B8JMH0; -.
DR   TreeFam; TF105983; -.
DR   PRO; PR:B8JMH0; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 2.
DR   Bgee; ENSDARG00000063446; Expressed in bone element and 31 other tissues.
DR   GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR   GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006783; P:heme biosynthetic process; IMP:ZFIN.
DR   GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR   Gene3D; 3.30.1360.120; -; 1.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   InterPro; IPR045179; YgfZ/GcvT.
DR   InterPro; IPR017703; YgfZ/GcvT_CS.
DR   PANTHER; PTHR22602; PTHR22602; 1.
DR   TIGRFAMs; TIGR03317; ygfZ_signature; 1.
PE   3: Inferred from homology;
KW   Heme biosynthesis; Mitochondrion; Reference proteome; Transferase;
KW   Transit peptide.
FT   TRANSIT         1..50
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           51..354
FT                   /note="Putative transferase CAF17 homolog, mitochondrial"
FT                   /id="PRO_0000386654"
SQ   SEQUENCE   354 AA;  39046 MW;  00D0F40294E46B2F CRC64;
     MQRMILFGGA LREIVVRSGG LQAHYFLCTS RTRIKTHSQT RAASSTAHFS CYRLPHRTVL
     NVSGQDTSSF LQGIITNDMN LLGEDSLNAM YAHVLNVQGR TLYDIILYSL KGNPDGLNGV
     LLECDSTVQD SVMQLLKVYK IRRKVNLSVC PSLSLWALLP HSKEAVLGRP DVTTTDKVLV
     LEKDPRTELM GWRMITSAQD NPLDIVSACR LGNTEEYHRH RYEIGLPEGV GDLPPGEALP
     LEANLVYMQG ISFSKGCYIG QELTARTHHT GVIRKRLMPV SLSAPAEKLN QGSALQTEGG
     KPAGKYRTGV DKLGLSLVRL AHAKETLQLK SSGDETVTVL ASVPDWWPKT PQEK