CAF17_MOUSE
ID CAF17_MOUSE Reviewed; 358 AA.
AC Q8CAK1; Q3T9H1;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Putative transferase CAF17 homolog, mitochondrial;
DE EC=2.1.-.-;
DE AltName: Full=Iron-sulfur cluster assembly factor homolog;
DE Flags: Precursor;
GN Name=Iba57;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Hypothalamus, Spleen, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen, and
RC Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [5]
RP SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-311, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23806337; DOI=10.1016/j.molcel.2013.06.001;
RA Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y.,
RA Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.;
RT "SIRT5-mediated lysine desuccinylation impacts diverse metabolic
RT pathways.";
RL Mol. Cell 50:919-930(2013).
RN [6]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-222 AND LYS-311, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=23576753; DOI=10.1073/pnas.1302961110;
RA Rardin M.J., Newman J.C., Held J.M., Cusack M.P., Sorensen D.J., Li B.,
RA Schilling B., Mooney S.D., Kahn C.R., Verdin E., Gibson B.W.;
RT "Label-free quantitative proteomics of the lysine acetylome in mitochondria
RT identifies substrates of SIRT3 in metabolic pathways.";
RL Proc. Natl. Acad. Sci. U.S.A. 110:6601-6606(2013).
CC -!- FUNCTION: Involved in the maturation of mitochondrial 4Fe-4S proteins
CC functioning late in the iron-sulfur cluster assembly pathway.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the GcvT family. CAF17 subfamily. {ECO:0000305}.
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DR EMBL; AK038625; BAC30069.1; -; mRNA.
DR EMBL; AK133203; BAE21556.1; -; mRNA.
DR EMBL; AK172525; BAE43049.1; -; mRNA.
DR EMBL; AL645854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC094909; AAH94909.1; -; mRNA.
DR CCDS; CCDS24758.1; -.
DR RefSeq; NP_776146.1; NM_173785.6.
DR AlphaFoldDB; Q8CAK1; -.
DR SMR; Q8CAK1; -.
DR IntAct; Q8CAK1; 1.
DR STRING; 10090.ENSMUSP00000049823; -.
DR iPTMnet; Q8CAK1; -.
DR PhosphoSitePlus; Q8CAK1; -.
DR SwissPalm; Q8CAK1; -.
DR EPD; Q8CAK1; -.
DR MaxQB; Q8CAK1; -.
DR PaxDb; Q8CAK1; -.
DR PeptideAtlas; Q8CAK1; -.
DR PRIDE; Q8CAK1; -.
DR ProteomicsDB; 273828; -.
DR Antibodypedia; 52265; 78 antibodies from 13 providers.
DR DNASU; 216792; -.
DR Ensembl; ENSMUST00000054523; ENSMUSP00000049823; ENSMUSG00000049287.
DR GeneID; 216792; -.
DR KEGG; mmu:216792; -.
DR UCSC; uc007jdd.2; mouse.
DR CTD; 200205; -.
DR MGI; MGI:3041174; Iba57.
DR VEuPathDB; HostDB:ENSMUSG00000049287; -.
DR eggNOG; KOG2929; Eukaryota.
DR GeneTree; ENSGT00390000006465; -.
DR HOGENOM; CLU_007884_7_1_1; -.
DR InParanoid; Q8CAK1; -.
DR OMA; MDRLHGV; -.
DR OrthoDB; 1342242at2759; -.
DR PhylomeDB; Q8CAK1; -.
DR TreeFam; TF105983; -.
DR BioGRID-ORCS; 216792; 22 hits in 73 CRISPR screens.
DR ChiTaRS; Iba57; mouse.
DR PRO; PR:Q8CAK1; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8CAK1; protein.
DR Bgee; ENSMUSG00000049287; Expressed in right kidney and 96 other tissues.
DR ExpressionAtlas; Q8CAK1; baseline and differential.
DR Genevisible; Q8CAK1; MM.
DR GO; GO:0005759; C:mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IBA:GO_Central.
DR Gene3D; 3.30.1360.120; -; 1.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR InterPro; IPR045179; YgfZ/GcvT.
DR InterPro; IPR017703; YgfZ/GcvT_CS.
DR PANTHER; PTHR22602; PTHR22602; 1.
DR TIGRFAMs; TIGR03317; ygfZ_signature; 1.
PE 1: Evidence at protein level;
KW Acetylation; Heme biosynthesis; Mitochondrion; Reference proteome;
KW Transferase; Transit peptide.
FT TRANSIT 1..94
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 95..358
FT /note="Putative transferase CAF17 homolog, mitochondrial"
FT /id="PRO_0000278634"
FT MOD_RES 222
FT /note="N6-acetyllysine"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 311
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23576753"
FT MOD_RES 311
FT /note="N6-succinyllysine; alternate"
FT /evidence="ECO:0007744|PubMed:23806337"
FT CONFLICT 267
FT /note="T -> A (in Ref. 1; BAE43049)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 358 AA; 38399 MW; 20DA23B0F14A764C CRC64;
MAAVALLRGA AVGRRSPAWH WRLSGTASHC LARGFGLLGS NPADGVAWTC FRLDGRALVR
VRGPDAAPFL LGLSTNELPL SGPPTGAAQP SARAAYAHFL NVQGRTLYDV ILYGLPECTE
GAPSFLLECD SSVLGALQKH LSMYKIRRKV TVEPSPELHV WAVLPCVPQT SETAPLEERV
EGTTMLIRDP RTARMGWRLL TQDDGPALVP RGQLGDLQDY HKYRYQQGIP EGVCDLPPGM
ALPLESNLVF MNGVSFTKGC YIGQELTART HHTGVIRKRL FPVKLEGPLP ASGVSPGAIV
TVTATGQAAG KFRAGQGHVG LALLRSETIK GPLHIKTSES QLVAVTAVVP DWWPTAAK
