ID   UVRC_ANADE              Reviewed;         707 AA.
AC   Q2IQH0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Adeh_1279;
OS   Anaeromyxobacter dehalogenans (strain 2CP-C).
OC   Bacteria; Proteobacteria; Deltaproteobacteria; Myxococcales;
OC   Cystobacterineae; Anaeromyxobacteraceae; Anaeromyxobacter.
OX   NCBI_TaxID=290397;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2CP-C;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Brettin T., Bruce D., Han C., Tapia R.,
RA   Gilna P., Kiss H., Schmutz J., Larimer F., Land M., Kyrpides N.,
RA   Anderson I., Sanford R.A., Ritalahti K.M., Thomas H.S., Kirby J.R.,
RA   Zhulin I.B., Loeffler F.E., Richardson P.;
RT   "Complete sequence of Anaeromyxobacter dehalogenans 2CP-C.";
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000251; ABC81053.1; -; Genomic_DNA.
DR   RefSeq; WP_011420336.1; NC_007760.1.
DR   AlphaFoldDB; Q2IQH0; -.
DR   SMR; Q2IQH0; -.
DR   STRING; 290397.Adeh_1279; -.
DR   EnsemblBacteria; ABC81053; ABC81053; Adeh_1279.
DR   KEGG; ade:Adeh_1279; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_7; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001935; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..707
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264864"
FT   DOMAIN          14..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          206..241
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   REGION          654..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   707 AA;  78948 MW;  DE913189BAE439B4 CRC64;
     MDANLRRKLD ELPAEPGCYL MKDRAGEVVY VGKASSLRSR VRSYFDAGRG DQRAFVALLD
     GLLGDLEVIV TRSEKEAVLL ENELIKKHRP RFNVRLRDDK DFIVLKLDER HPYPRLEVRR
     AREKRQPGAR YFGPYSSASS IRETLRMVNR HFQLRTCSDH VFDHRKRPCI LYQIHRCPAP
     CVYEVPAEEY RQSVEDAVEF LEGREGELVE RLRGRMAGAA EGLRFEEAAR LRDQLQAVER
     SLEKQRVLMS DRGDRDVIGL YREGPDLVVQ VLSMRAGKLQ DAQAHPFREQ EFPAEEILSS
     FLSLYYEHTD APDEILVPLE PVQAEALADV LSERRGRRVR LLTPQRGAKA DLLDVARRNA
     EQGFRAWHEH DERREQALAS LAKALHLARP PRWMECYDIS TFQGALAVGS GVSMKDGEPD
     KANYRRYKVK AVAGQDDFAM LHEVVTRRLR RALGEGQLPD LIVIDGGKGQ LNAALAAAKD
     LGVPTRPSPG NPDAPFVELV GLAKSRLVDG PALGTARVVA RRGRRAEARL ADAAEAAEKG
     FVSELARSPE RVFLPGRKDP VVLRQNSAEL FLLARLRDEA HRFAITFHRK LRRERNFQSV
     LEEIPGIGEG RKRALLRHFG ALRRVREATP EEIAQVEGFG PRQAAAVHAF FHRPDAPPAA
     ADEPSGAPEG TPAGGPAEAI PDAAIAATEA EIDAALADED ASPEPAA