ID   UVRC_AQUAE              Reviewed;         566 AA.
AC   O67887;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=aq_2126;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE000657; AAC07850.1; -; Genomic_DNA.
DR   PIR; C70482; C70482.
DR   RefSeq; NP_214456.1; NC_000918.1.
DR   RefSeq; WP_010881392.1; NC_000918.1.
DR   AlphaFoldDB; O67887; -.
DR   SMR; O67887; -.
DR   STRING; 224324.aq_2126; -.
DR   PRIDE; O67887; -.
DR   EnsemblBacteria; AAC07850; AAC07850; aq_2126.
DR   KEGG; aae:aq_2126; -.
DR   PATRIC; fig|224324.8.peg.1641; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_0; -.
DR   InParanoid; O67887; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..566
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000138286"
FT   DOMAIN          16..93
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          199..234
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   566 AA;  65596 MW;  9AE6E2AD3E16F434 CRC64;
     MAKTGKVENL IQNAPEKPGV YLFKKGNRPI YIGKAKNLKK RLLQHLKASE YDSKERAIIS
     NSDNLEWIVT RNEYEALVLE IDLIQQYKPR YNVLHKFGGG YPMLLLTKDE YPTIKVVRGT
     EHEGELFGPF LQSKKAYKVK KLIHNLFKLR TCDPLPKRSE PCMDYHLGLC SAPCCGFVSK
     EEYELAVSSA RALLTGEVAE VLPKLYEKIE EFSKELMFEK CAHIRDQIIA LENLAKGQAV
     SALPFREGDI FYKFGSRLGL LLVRSSKLVS KEIFDLESDE EVEEVILGYY YSNYVPRKVI
     TNFELSEEVK EWIRNRAKGE VEFSGEIPKE LKEVLEENLG EGINEEVLKK EFAEKLGMPV
     PRVIEGFDIS HFYGEDIVGS CVVWKGGKMS KKDYRRYKVK TISRIDDYLA LEEVLTRRAK
     RILKGEVEKP DIWLIDGGKG QLNVGIRVKK RTGLDVKVFS LAKEEEIIYT EDGREIRLKE
     NPILYRVFGE IRDEAHRFAL SYNRKLREKR YMEDILSKIK GIGEQKKKII YKNFETLYDF
     IEAKDEELRR LGINPSLKQE VKKWLS