ID   UVRC_BACC0              Reviewed;         594 AA.
AC   B7JR24;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203};
GN   OrderedLocusNames=BCAH820_4632;
OS   Bacillus cereus (strain AH820).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=405535;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AH820;
RA   Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A.,
RA   Ravel J., Sutton G.;
RT   "Genome sequence of Bacillus cereus AH820.";
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001283; ACK91537.1; -; Genomic_DNA.
DR   RefSeq; WP_000544275.1; NC_011773.1.
DR   AlphaFoldDB; B7JR24; -.
DR   SMR; B7JR24; -.
DR   EnsemblBacteria; ACK91537; ACK91537; BCAH820_4632.
DR   KEGG; bcu:BCAH820_4632; -.
DR   HOGENOM; CLU_014841_3_2_9; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001363; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..594
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000200569"
FT   DOMAIN          14..91
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          196..231
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   594 AA;  68370 MW;  F1F30466B8876465 CRC64;
     MHEHLKEKLA ILPDQPGCYL MKDKQGTVIY VGKAKVLKNR VRSYFTGSHD GKTLRLVGEI
     VDFEYIVTSS NLEALILELN LIKKHDPKYN IQLKDDKTYP FIKITAEKQP RLLITRNVKK
     DKGKYFGPYP NAQSAHETKK LLDRMYPLRK CSNMPDKVCL YYHMGQCLAP CVKEVTEEQN
     KEIVDEIIKF LNGGHKEVRS ELETKMYEAS EKLEFERAKE LRDQIAHIDA IMEKQKMIMS
     DLVDRDVFGY AVDKGWMCVQ VFFVRKGKLI ERDVSMFPIY DEPEEGFLTF IGQFYENSSH
     FKPKEIVVPG SIDSELVERF LEVEATQPKR GKKKDLVELA NKNAKIALEE KFYLIERDEE
     RTIKAVENLG KQLGIETPYR IEAFDNSNIQ GTNPVSAMIA FIDGKPAKKE YRKYKIKTVQ
     GPDDYESMRE VVRRRYTRAL KEGLPLPDLI IIDGGKGHLA AASDVLENEL GLYIPMAGLV
     KDDKHKTSHL IIGDPPEPVM LERNSQEFYL LQRVQDEVHR FAITFHRQLH GKSVIQSALD
     DIPGIGDKRK KVLLKHFGSL KKMKEASIEE FVEAGMPKNV AETIYTYLTD KKTL