ID   UVRC_BACFR              Reviewed;         608 AA.
AC   Q650H7;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BF0098;
OS   Bacteroides fragilis (strain YCH46).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=295405;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YCH46;
RX   PubMed=15466707; DOI=10.1073/pnas.0404172101;
RA   Kuwahara T., Yamashita A., Hirakawa H., Nakayama H., Toh H., Okada N.,
RA   Kuhara S., Hattori M., Hayashi T., Ohnishi Y.;
RT   "Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions
RT   regulating cell surface adaptation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14919-14924(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AP006841; BAD46847.1; -; Genomic_DNA.
DR   RefSeq; WP_005783702.1; NZ_UYXF01000007.1.
DR   RefSeq; YP_097381.1; NC_006347.1.
DR   AlphaFoldDB; Q650H7; -.
DR   SMR; Q650H7; -.
DR   STRING; 295405.BF0098; -.
DR   EnsemblBacteria; BAD46847; BAD46847; BF0098.
DR   KEGG; bfr:BF0098; -.
DR   PATRIC; fig|295405.11.peg.136; -.
DR   HOGENOM; CLU_014841_3_2_10; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000002197; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..608
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227400"
FT   DOMAIN          22..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          214..249
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   608 AA;  70197 MW;  9261A6724568B2FC CRC64;
     MDTNQELKTS EYLKGIVSNL PEKPGIYQYL NAEGTIIYVG KAKNLKRRVY SYFSKEHQPG
     KTRVLVSKIA DIRYIVVNSE EDALLLENNL IKKYKPRYNV LLKDDKTYPS ICVQNEYFPR
     VFKTRRIIRN GSSYYGPYSH SPSMHAVLDL IKHLYPLRTC NLNLSPENIR AGKFNVCLEY
     HIKNCAGPCI GLQSQEEYLK NIAEIKEILK GNTQEISRLL YQRMQDLAAE MKFEEAQKVK
     EKYALIENYR SKSEVVSSVL HNIDVFSIEE DGEKSAFINY LHITNGAINQ AFTFEYKKKL
     NETKEELLTL GIIEMRERYK SASREIIVPF DIEIELNDVT FTIPQRGDKK KLLELSLLNV
     KQYKADRMKQ AEKLNPEQRS MRLMKEIQQE LHLDRLPMQI ECFDNSNIQG TDAVAACVVF
     KKAKPSKSDY RKYNIKTVVG ADDYASMKEV VRRRYQRAIE EESPLPDLII TDGGKGQMEV
     VRQVMEELQL DIPIAGLAKD RKHRTSEVLF GFPPQTIGIK QHSPLFRLLE QIQDEVHRFA
     ITFHRDKRSK RQVASALDNI KGIGEKTKTA LLKEFKSVKR IKEATIEEVS AIIGESKAKI
     IKEGLDNH