ID   UVRC_BACTN              Reviewed;         609 AA.
AC   Q8A2N9;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BT_3266;
OS   Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS   CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC   Bacteria; Bacteroidetes; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC   Bacteroides.
OX   NCBI_TaxID=226186;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC   VPI-5482 / E50;
RX   PubMed=12663928; DOI=10.1126/science.1080029;
RA   Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA   Hooper L.V., Gordon J.I.;
RT   "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL   Science 299:2074-2076(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; AE015928; AAO78372.1; -; Genomic_DNA.
DR   RefSeq; NP_812178.1; NC_004663.1.
DR   RefSeq; WP_011108727.1; NZ_UYXG01000003.1.
DR   AlphaFoldDB; Q8A2N9; -.
DR   SMR; Q8A2N9; -.
DR   STRING; 226186.BT_3266; -.
DR   PaxDb; Q8A2N9; -.
DR   PRIDE; Q8A2N9; -.
DR   EnsemblBacteria; AAO78372; AAO78372; BT_3266.
DR   GeneID; 60924446; -.
DR   KEGG; bth:BT_3266; -.
DR   PATRIC; fig|226186.12.peg.3331; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_10; -.
DR   InParanoid; Q8A2N9; -.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000001414; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; IBA:GO_Central.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..609
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000227402"
FT   DOMAIN          22..100
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          214..249
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   609 AA;  70186 MW;  D05444F98D5BB692 CRC64;
     MNTEPEAKTN EYLRGIVANL PEKPGVYQYL NTEGTIIYVG KAKNLKKRVY SYFSKEHEPG
     KTRVLVSKIA DIRYIVVNTE EDALLLENNL IKKYKPRYNV LLKDDKTYPS ICVQNEYFPR
     IFRTRKIIKN GSSYYGPYSH LPSMYAVLDL IKHLYPLRTC NLNLSPENIR AGKFKVCLEY
     HIKKCAGPCV GLQSHEDYLK NIDEIKEILK GNTQDISRML VEKMQELANE MKFEEAQKIK
     EKYLLIENYR SKSEVVSSVL HNIDVFSIEE DDSNSAFVNY LHITNGAINQ AFTFEYKKKL
     NESKEELLTL GIIEMRERYK SHSREIIVPF ELDLELNNVV FTVPQRGDKK KLLDLSILNV
     KQYKADRLKQ AEKLNPEQRS MRLLKEIQNE LHLDKPPLQI ECFDNSNIQG SDAVAACVVF
     KKAKPSKKDY RKYNIKTVVG PDDYASMKEV VRRRYQRAIE ENSPLPDLII TDGGKGQMEV
     VREVIEDELH LNIPIAGLAK DNKHRTSELL FGFPAQTIGI KQQSSLFRLL TQIQDEVHRF
     AITFHRDKRS KRQVASALDS IKGIGEKTKT ALLKEFKSVK RIKEASLEEI AKVIGEVKAQ
     TVKKGLSNE