ID   UVRC_BARHE              Reviewed;         661 AA.
AC   Q6G424;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BH05550;
OS   Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1)
OS   (Rochalimaea henselae).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Bartonellaceae; Bartonella.
OX   NCBI_TaxID=283166;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49882 / DSM 28221 / Houston 1;
RX   PubMed=15210978; DOI=10.1073/pnas.0305659101;
RA   Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H.,
RA   Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M.,
RA   La Scola B., Holmberg M., Andersson S.G.E.;
RT   "The louse-borne human pathogen Bartonella quintana is a genomic derivative
RT   of the zoonotic agent Bartonella henselae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; BX897699; CAF27363.1; -; Genomic_DNA.
DR   RefSeq; WP_011180485.1; NZ_LRIJ02000001.1.
DR   AlphaFoldDB; Q6G424; -.
DR   SMR; Q6G424; -.
DR   STRING; 283166.BH05550; -.
DR   PaxDb; Q6G424; -.
DR   EnsemblBacteria; CAF27363; CAF27363; BH05550.
DR   GeneID; 64156834; -.
DR   KEGG; bhe:BH05550; -.
DR   eggNOG; COG0322; Bacteria.
DR   OMA; HIECFDN; -.
DR   Proteomes; UP000000421; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR041663; DisA/LigA_HHH.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF12826; HHH_2; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..661
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264867"
FT   DOMAIN          52..130
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          240..275
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   661 AA;  75293 MW;  99671A799EF48490 CRC64;
     MILKNNIAYA ENEQEKLSFL SHITWDDAHQ RNDKNQFKGA KLIQEFVKHL PHKPGVYRMV
     DENGKVLYVG KARNLKKRVS NYTREQGHNN RITRMIRATS HMEFVVTHTE IEALLLEANL
     IKRLHPRFNV LLRDDKSFPY IIITDDHRAP ALYKHRGART RKAHYFGPFA SSSAVTQTIN
     VLQRAFLLRT CTDSVLENRT RPCLLYQIKR CSAPCTHEIS DRDYRELVKG AKSFLSGKSQ
     SIKNDMVQAM HKAAKNFDFE QAAAYRDRLS ALSHIQSHQG INPQTIEEAD VFAIAQKEGI
     SCIQVFFFRM GQNWGNRAYF PKADPSFSSS EILASFLSQF YDDKPLPKLI LLSESIEDKT
     LLAEAFSLKA NRKISLSLPK QGERKTLVNY AYINAHETLG HKLAETATHT KLFQGIAEIF
     QLPHTPCRIE IYDNSHIMGT NAVGAMIVAG KNGFIKNQYR KFNIRSTDIT PGDDFGMMKE
     VIKRRFSRLI KEHGLPHESK NIQSKDDASF PIWPDLILID GGKGQINSVH TILSELGLDN
     FMTVVGIAKG ADRRAGRERF FIKGKTPFTL PPCDPILYFL QRLRDEAHRF AIGTHRAKRK
     KETLKNPLDE IENIGPTRKR ALLHHFGSAK AIASASLEDL TKVIGISTTI AQKIYNHFNE
     K