ID   UVRC_BORA1              Reviewed;         607 AA.
AC   Q2KXM9;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BAV2456;
OS   Bordetella avium (strain 197N).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Bordetella.
OX   NCBI_TaxID=360910;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=197N;
RX   PubMed=16885469; DOI=10.1128/jb.01927-05;
RA   Sebaihia M., Preston A., Maskell D.J., Kuzmiak H., Connell T.D., King N.D.,
RA   Orndorff P.E., Miyamoto D.M., Thomson N.R., Harris D., Goble A., Lord A.,
RA   Murphy L., Quail M.A., Rutter S., Squares R., Squares S., Woodward J.,
RA   Parkhill J., Temple L.M.;
RT   "Comparison of the genome sequence of the poultry pathogen Bordetella avium
RT   with those of B. bronchiseptica, B. pertussis, and B. parapertussis reveals
RT   extensive diversity in surface structures associated with host
RT   interaction.";
RL   J. Bacteriol. 188:6002-6015(2006).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAJ50066.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AM167904; CAJ50066.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_039051595.1; NC_010645.1.
DR   AlphaFoldDB; Q2KXM9; -.
DR   SMR; Q2KXM9; -.
DR   STRING; 360910.BAV2456; -.
DR   PRIDE; Q2KXM9; -.
DR   EnsemblBacteria; CAJ50066; CAJ50066; BAV2456.
DR   GeneID; 41394294; -.
DR   KEGG; bav:BAV2456; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_0_4; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001977; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SMART; SM00278; HhH1; 2.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   Reference proteome; SOS response.
FT   CHAIN           1..607
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264870"
FT   DOMAIN          16..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          203..238
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   607 AA;  66965 MW;  2A8ABF1DB1BB5FA9 CRC64;
     MPDEFNLKSF LADLPHLPGV YRHLDAAGEV MYVGKARDLK KRVSSYFQKT LASPRIAQMV
     SKVVRLEVTV TRSEAEALIL ENNLIKSLRP RYNILFRDDK SYPYLLITAH EWPRIAYYRG
     STSKRGQYFG PYPNSWAVRE TIQILQKVFR LRTCEDTVFA NRSRPCLLYQ IGRCSGPCVQ
     AIDAEDYRRD VQRAARFLNG EAREVMDEIE ARMQQASGEL RFEEAAVLRD QMGSLSKVLH
     QQTMENVGGE DTDVIAVASA GGKVCVNLAM VRGGRHLGDK PFFPSHADGE EAAQVQEAFI
     AQHYADNVLP PVLVCSHALP DVDLIGLLSE QAGTRCRVLT RPQGVRRSWL EQAQKNAEMA
     LARALTESGA RAARTLSLAE ALDLDTDEAA LDALRIECFD ISHTAGEATQ ASCVVFLHHD
     MQPSLYRRYN IVGITPGDDY AAMRQVLTRR FAKVTDGEAP MPGLVLIDGG KGQVEVARQV
     FVELGLDIGA LVGVAKGEGR KVGLETLVFA DARAPLALGK ASAALMLIAQ VRDEAHRFAI
     TGMRAKRAKT RNVSRLEEIE GVGAKRRQRL LARFGGLSGV TSASIEDLAS VDGISMDLAE
     RIYDALH