ID   UVRC_BORBZ              Reviewed;         603 AA.
AC   B7J223;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BbuZS7_0464;
OS   Borreliella burgdorferi (strain ZS7) (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=445985;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZS7;
RX   PubMed=20935092; DOI=10.1128/jb.01158-10;
RA   Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J.,
RA   Mongodin E.F., Luft B.J.;
RT   "Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.";
RL   J. Bacteriol. 193:1018-1020(2011).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP001205; ACK74967.1; -; Genomic_DNA.
DR   RefSeq; WP_002657940.1; NC_011728.1.
DR   AlphaFoldDB; B7J223; -.
DR   SMR; B7J223; -.
DR   PRIDE; B7J223; -.
DR   EnsemblBacteria; ACK74967; ACK74967; BbuZS7_0464.
DR   GeneID; 56567889; -.
DR   KEGG; bbz:BbuZS7_0464; -.
DR   HOGENOM; CLU_014841_3_2_12; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000006901; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..603
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000200573"
FT   DOMAIN          17..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   603 AA;  69833 MW;  B9EDDDB6B4A63484 CRC64;
     MKENLTNLFE KVIKLPTTSG CYKMLNENKK ILYIGKAKNL RSRVKSYFLE KNSHKIKILM
     KNVKSIEVIT TNSEYEALLL ECNLIKTHKP DYNVKLKDGK GYPMVRITHE KYPRIFKTRK
     IINDKSEYFG PFTNVKKLDQ VLDFINKTFK IRKCKKKSNA PCLYYHMGQC LGVCYKENLE
     KEYQKELDKA KSILNGNISE ISSQIDIKLK HAIQKEDFET AIKLKEIRNS LIEINQIQIV
     TKTNNLNIDY VHVHPGENVN TIIVLKYRNG KLVERDANFD ESICKENELI LQFLIQYYTS
     INMIVPDKIH IFLKDIDTKN VEKLINEIKN TKTEIIYKET EEILKIMEMA ISNAELSLRE
     YENKSTKALE SLKIVLEMDK LPKIIEGFDI AHLKGQETVA SMVTFKMGMP FKENYRLYKL
     NSLLKGEIDD FKAIKEVISR RYSEIINNNL ELPNLILIDG GKGQLNAALS ILKGLKIENK
     VKVCSLAKKQ ETIFLTTNKK GINLPQGHPA LRILQNVRDE AHRKANGFNK KRREKITLLY
     TKIHGIGEKT AQKILKSIGT YKDILPLSEN EISEKIKVNV QLAKRIKEFA IKENSIKNNN
     QDK