ID   UVRC_BORGP              Reviewed;         603 AA.
AC   Q661G2;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 2.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BG0466;
OS   Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 /
OS   PBi) (Borrelia bavariensis).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=290434;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-2496 / DSM 23469 / PBi;
RX   PubMed=15547252; DOI=10.1093/nar/gkh953;
RA   Gloeckner G., Lehmann R., Romualdi A., Pradella S., Schulte-Spechtel U.,
RA   Schilhabel M., Wilske B., Suehnel J., Platzer M.;
RT   "Comparative analysis of the Borrelia garinii genome.";
RL   Nucleic Acids Res. 32:6038-6046(2004).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAU07309.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000013; AAU07309.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_044007889.1; NZ_CP028872.1.
DR   AlphaFoldDB; Q661G2; -.
DR   SMR; Q661G2; -.
DR   STRING; 290434.BG0466; -.
DR   EnsemblBacteria; AAU07309; AAU07309; BG0466.
DR   KEGG; bga:BG0466; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_12; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000002276; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..603
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_0000264874"
FT   DOMAIN          17..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          199..234
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   603 AA;  69792 MW;  AB8DB5C186708945 CRC64;
     MKEALTSLFE KVTKLPTTSG CYKMLNENKK ILYIGKAKNL RSRIKSYFLE KKSHKIKILM
     KNVKSIEVIT TNSEYEALLL ECNLIKTHKP DYNVKLKDGK GYPMIRITHE KYPRILKTRK
     IINDQSEYFG PFTNVKKLDQ VLDFINKTFK IRKCKKKSNA PCLYYHMGQC LGVCYKENLE
     KEYQIEVNKA KSILNGNISE ILSQIDIKLK LAVQKEDFET AIKLKEMKSS LIEINQIQIV
     TKANNLNIDY VYVHPGENVN TIIVLKYRDG KLVERDANFD ESICKKDELV LQFLIQYYTS
     INMIVPDKIH IFLKDVDTKN VEKLINEIKN TKTEIIYKET KEILKIMEMA ISNAKLSLRE
     YENKSNKALE SLKIFLEMDK LPKIIEGFDI AHLKGQETVA SMVTFKMGIP FKENYKLYKL
     NSLLKGEIDD FRAIKEAILR RYSEIINKKL ELPNLILIDG GKGQLSAAFS ILKSLKIEDK
     VKVCSLAKKH ETIFLITNKK GINLPQGHPA LRILQNVRDE AHRKANGFNK KRREKITLLY
     KKIDGVGEKT AQKILKLIGT YKDILPLSEN EISEKIKVNI KLAKRIKEFA IKENSIKNID
     NDK