ID   UVRC_BORHD              Reviewed;         602 AA.
AC   B2S0F9;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BH0457;
OS   Borrelia hermsii (strain HS1 / DAH).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=314723;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HS1 / DAH;
RA   Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T.,
RA   Schwan T.G.;
RT   "The genome sequence of Borrelia hermsii and Borrelia turicatae:
RT   comparative analysis of two agents of endemic N. America relapsing fever.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000048; AAX16965.1; -; Genomic_DNA.
DR   RefSeq; WP_012422221.1; NC_010673.1.
DR   AlphaFoldDB; B2S0F9; -.
DR   SMR; B2S0F9; -.
DR   PRIDE; B2S0F9; -.
DR   KEGG; bhr:BH0457; -.
DR   HOGENOM; CLU_014841_3_2_12; -.
DR   OMA; HIECFDN; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..602
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000099461"
FT   DOMAIN          17..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          199..234
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   602 AA;  69933 MW;  6E94C155DF47DE12 CRC64;
     MREHLNHLHK KVQELPTTSG CYKMYSQNNK ILYIGKAKNL RARVKNYFLK RISHKTKILM
     RNVANIEVIT TNSEYEALLL ECNLIKEYKP DYNIKLKDDK GYPMIRITCE KYPRIFKTRK
     IINDGSEYFG PYVNAKNLDL VLDLINKTFK TRKCKKKSKT PCLYFHMGQC LGVCYREDLE
     EQYKKEVDKI RHILNGKISK LLDETEIKMK EAIKKEDFEA AIKLKETKRS LIEISQTQII
     TRMNKLSADY IYIHQTDSLN AIVILKYKDG KLVEKDINFD ESIYEEDELT AKFITQYYTA
     LNMIVPNKIY IFKKIETENI TKLINELKNT KTEIICEETK ETIKIMEMAI SNAKIALREY
     DNEKNRALES LKNILEMTKL PKTIEGFDIS HLNGHKTVAS LVSFKMGKPF KDGYRVYKIN
     SLNNGEIDDL KAIKEVISRR YSKLINEQLA LPDLILIDGG KGQLSAAYSI LKGLKIENEV
     IVCALAKKEE IIFLPNKTQG IKLSKGNPAL QILQNVRDEA HRRANSFNRT LRRNIKLNYS
     KIKGIGEEKA KNILKTLGTY KDILLLNEDE IAKKMKINIK MAKKIKKFSE DQNLKNTYSI
     KS