ID   UVRC_BORT9              Reviewed;         602 AA.
AC   A1QZP2;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   25-MAY-2022, entry version 75.
DE   RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE            Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE   AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN   Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=BT0457;
OS   Borrelia turicatae (strain 91E135).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borrelia.
OX   NCBI_TaxID=314724;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91E135;
RA   Porcella S.F., Raffel S.J., Schrumpf M.E., Montgomery B., Smith T.,
RA   Schwan T.G.;
RT   "The genome sequence of Borrelia hermsii and Borrelia turicatae:
RT   comparative analysis of two agents of endemic N. America relapsing fever.";
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC       lesion. The N-terminal half is responsible for the 3' incision and the
CC       C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC       {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC   -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00203}.
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DR   EMBL; CP000049; AAX17784.1; -; Genomic_DNA.
DR   RefSeq; WP_011772403.1; NC_008710.1.
DR   AlphaFoldDB; A1QZP2; -.
DR   SMR; A1QZP2; -.
DR   STRING; 314724.BT0457; -.
DR   PRIDE; A1QZP2; -.
DR   KEGG; btu:BT0457; -.
DR   eggNOG; COG0322; Bacteria.
DR   HOGENOM; CLU_014841_3_2_12; -.
DR   OMA; HIECFDN; -.
DR   OrthoDB; 1036075at2; -.
DR   Proteomes; UP000001205; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.340; -; 1.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR000305; GIY-YIG_endonuc.
DR   InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR036876; UVR_dom_sf.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_RNase_H_dom.
DR   InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW   SOS response.
FT   CHAIN           1..602
FT                   /note="UvrABC system protein C"
FT                   /id="PRO_1000200574"
FT   DOMAIN          17..94
FT                   /note="GIY-YIG"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT   DOMAIN          199..234
FT                   /note="UVR"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ   SEQUENCE   602 AA;  70047 MW;  04C437C2CDC939A7 CRC64;
     MREHLNCLHK KVQEFPTTSG CYKMYSQDNK ILYIGKAKNL RSRLKNYFLE KISLKTKILM
     RNVVNIEVIT TNSEYEALLL ECNLIKEHKP DYNIKLKDDK GYPMIRITCE KYPKVFKTRK
     IINDGSEYFG PYVNAKHLDL VLNLINKTFK TRKCKKKSKN PCLYFHMGQC LGVCYRNDLE
     EQYKEEVNKI RHILNGNISK LLDEIEIKMK EVIKREDFES AIKLKETKRS LIEISQTQII
     TKINKLSTDY IYIHKTDNLN VIVIFKYKDG KLVEKDINFD ESIYEEEELI AEFITQYYTS
     LNMIVPDKIC IFKKIETEDI TKLINELKST NTEIVYEETK DAIKIMEMAI SNAEIALKAY
     NNEKNKALEN LKIILEMTKL PKTIEGFDIA HLNGYKTVAS LVTFKMGKPF KDGYRVYKIN
     SLNDGEINDF KAIKEIISRR YTKLINEQLE LPTLILIDGG KGQLNAAYSI LKGLKIEDKV
     TICALAKQEE TIFLPNKTQG IKLPKGNPAL KILQNVRDES HRKANSFNRK LRKNIKLNYS
     KIEGIGEKKA KNILKTLGTY KDIFLLNEDE IAQKMKINIK MAKKIKKFSE DQNLKNTHSI
     ES